Joydeb Sinha on Muck Rack

Joydeb Sinha

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The H3.3 K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation

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By Abby R. Thurm, Connor Ludwig, Joydeb Sinha, Jan F Nickels
| biorxiv.org
Abstract Histone H3.3 is frequently mutated in cancers, with the lysine 36 to methionine mutation (K36M) being a hallmark of chondroblastomas. While it is known that H3.3K36M changes the cellular epigenetic landscape, it remains unclear how it affects the dynamics of gene expression.
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