Juat Chin Foo on Muck Rack

Juat Chin Foo

As seen in: Nature, The Journal of Biological Chemistry
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Articles

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

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By Juat Chin Foo, Thiet M. Vu, Ayako-Nakamura Ishizu, Xiu Ru Toh
| Nature Verified
Sphingosine-1-phosphate (S1P), a potent signalling lipid secreted by red blood cells and platelets1,2, plays numerous biologically significant roles3,4,5,6. However, the identity of its long-sought exporter is enigmatic. Here we show that the major facilitator superfamily transporter 2b (Mfsd2b), an orphan transporter, is essential for S1P export from red blood cells and platelets.
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Mfsd2a is a transporter for the essential omega-3 fatty acid DHA in eye and important for photoreceptor cell development

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By Bernice Wong, Jia Pei Chan, Amaury Cazenave-Gassiot, Rebecca W. Poh, Juat Chin Foo
| The Journal of Biological Chemistry Verified
Eye photoreceptor membrane discs in outer rod segments (OS) are highly enriched in the visual pigment rhodopsin and the omega-3 fatty acid docosahexaenoic acid (DHA). The eye acquires DHA from blood, but transporters for DHA uptake across the blood-retinal barrier (BRB) or retinal pigment epithelium (RPE) have not been identified.
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