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1Medical Oncology, Lyon University Hospital, EPSILyon, Lyon, France 2CICLY, Claude Bernard University Lyon 1, University of Lyon, Lyon, France 3GINECO, Paris, France 4The Christie NHS Foundation Trust and University of Manchester, Manchester, United Kingdom 5Fred & Pamela Buffett Cancer Center at Nebraska Medicine, Omaha 6Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada 7Department of Obstetrics and Gynecology, Hillel Yaffe...
Abstract The response of breast cancer to neoadjuvant chemotherapy (NAC) varies substantially, even when tumours belong to the same molecular or histological subtype1. Here we identify the oestrous cycle as an important contributor to this heterogeneity. In three mouse models of breast cancer, we show reduced responses to NAC when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus stage.
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