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Julia Morud

As seen in: Cell Press, JNeurosci
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Articles by Julia Morud

A Novel and Functionally Diverse Class of Acetylcholine-Gated Ion Channels

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By Iris Hardege, Julia Morud, Amy N Courtney, William Schafer
| JNeurosci Verified
C. elegans culture. Unless otherwise specified, C. elegans hermaphrodite worms were cultured on NGM (normal growth media) agar plates with OP50 (Stiernagle, 2006). A full list of strains used in this study can be found in Extended Data Table 4-1. Xenopus laevis oocytes. Defolliculated Xenopus laevis oocytes were obtained from EcoCyte Bioscience and maintained in ND96 solution as follows (in mm): 96 NaCl, 1 MgCl2, 5 HEPES, 1.8 CaCl2, and 2 KCl, at 16°C for 3–7 d. Molecular biology.
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Deorphanization of novel biogenic amine-gated ion channels identifies a new serotonin receptor for learning

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By Francis Crick, Julia Morud, Iris Hardege
| Cell Press Verified
Highlights • Characterization of five new monoamine-gated ion channels in C. elegans • The serotonin-gated cation channel LGC-50 is required for aversive learning • Pathogen exposure redistributes LGC-50 to synaptic processes • Regulated trafficking of LGC-50 is critical for the learning mechanism Summary Pentameric ligand-gated ion channels (LGICs) play conserved, critical roles in both excitatory and inhibitory synaptic transmission and can be activated by diverse neurochemical ligands.
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