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William Schafer

As seen in: Nature, Chicago Tribune, Cell Press, JNeurosci, Kirkus Reviews, EOS Wetenschap, Edgerton Enterprise
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Articles

DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings

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By Larissa Ferguson, Sebastien Ouellet, Elke Vandewyer, Christopher Wang, Tony K.Y. Lim, William Schafer, Isabel Beets, Zaw Wunna
| Cell Press Verified
Results We leveraged a previously published dataset that employed a high-throughput Chinese hamster ovary (CHO) Gα16-mediated calcium signaling assay to screen peptide agonist activity across 161 putative peptide-activated GPCRs from C.
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Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species

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By Itai Antoine Toker, Lidia Ripoll-Sánchez, Luke Geiger, Antoine Sussfeld, Isabel Beets, Petra E. Vértes, William Schafer, Eyal Ben-David, Oliver Hobert
| Cell Press Verified
Keywords nervous system evolution neuronal cell types C. elegans C. briggsae C. tropicalis neuronal signaling neuropeptides GPCRs small secreted proteins Introduction Evolutionary changes that shaped animal nervous systems played a pivotal role in their success in adapting to diverse environments. Characterizing these changes has been the goal of numerous comparative studies that enlightened our understanding of brain evolution.
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The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabiditis elegans

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By Lorenzo Rossi, Kenneth Amoako, Inka Busack, Luca Golinelli, Amy N Courtney, Judith Besseling, William Schafer, Isabel Beets, Henrik Bringmann
| Cell Press Verified
ReportOnline nowOpen access 1Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Am Tatzberg 47/49, 01307 Dresden, Germany 2Department of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium 3MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK 4Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany 5Faculty of Medicine Carl Gustav Carus,...
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