Juliati Rahajeng

Highlights • DNA damage triggers Golgi dispersal • DNA damage signals directly to the Golgi via DNA-PK phosphorylation of GOLPH3 • Golgi proteins GOLPH3 and MYO18A are required for survival after DNA damage • GOLPH3 overexpression, as seen in cancer, confers resistance to DNA-damaging agents Summary The response to DNA damage, which regulates nuclear processes such as DNA repair, transcription, and cell cycle, has been studied thoroughly.

Highlights • GOLPH3 induces curvature of liposomes in vitro and the Golgi in cells • GOLPH3 induces curvature by insertion of a hydrophobic β-loop into the bilayer • Efficient Golgi-to-plasma membrane trafficking depends on GOLPH3-induced curvature • Golgi-to-plasma membrane trafficking also requires GOLPH3 interaction with MYO18A Summary Vesicle budding for Golgi-to-plasma membrane trafficking is a key step in secretion.