Julica Inderhees

Results Initially, we examined a public domain dataset containing single-cell RNA sequencing (scRNA-seq) data to find evidence of PCK1 expression in human HSCs. To this end, we analyzed a recent scRNA-seq dataset encompassing individuals without liver damage and those with cirrhotic livers, whose HSC have been classified as quiescent (cyHSC) or activated (myHSC).18 Overall, the total number of PCK1-positive cells is lower in the cirrhotic liver (109 cells, 5%) and HCC (55 cells, 20%),...

Accepted manuscript, PDF only. Full online edition to follow. Accepted Manuscript April 23, 2025 Share this article Cite this article Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR eLife 14:e98970. https://doi.org/10.7554/eLife.98970 Data availability Raw RNA sequencing data have been deposited in Gene Expression Omnibus under accession number GSE263752.