Julie Bragg

Abstract The tumor extracellular matrix (ECM) is increasingly recognized as a key driver of immune suppression and therapy resistance in cancer. However, the specific ECM components and mechanisms that create this immunosuppressive environment remain poorly understood, hindering the development of new therapies. Here, we use comprehensive multi omics profiling of triple-negative breast cancer (TNBC), an aggressive and treatment-resistant subtype, to investigate this issue.

RICHMOND, Va. — 8-year-old Kasen Diggs is a massive fan of golf. He has his own putting green, a golf cart, and a personal parking space in the driveway drawn with sidewalk chalk. Golf is his passion, and when he was faced with a cancer diagnosis and seemingly endless tubes and IVs in the hospital, the sport served as a motivator. "He was just tied to the bed, he wouldn't get out of bed for anything," said Kasen's mother, Claudia.

DOSWELL, Va. — One of Virginia’s largest holiday light shows is shining bright again. The Illuminate Light Show, a 2.5-mile drive-through spectacle of more than 3 million synchronized LED lights, is drawing families back for festive fun at Meadow Event Park. The annual event pairs dazzling displays with holiday music from visitors’ car radios.