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CD40/PI3K/FOXO1 axis rewiring drives microenvironment-dependent BIM silencing to sustain lymphoma growth and survival - Leukemia
Abstract Both solid and hematological malignancies are recognized as complex ecosystems in which the tumor microenvironment (TME) plays a pivotal role in mediating therapeutic resistance. TME-driven modulation of BCL2-family proteins has emerged as a key determinant of treatment response in B-cell malignancies. Here, we focused on the regulation of the pro-apoptotic BH3-only protein BIM, using mantle cell lymphoma (MCL), an aggressive and incurable B-cell neoplasm, as a cellular model.
Exploring cardiac phenotypes of Drosophila orthologues of human genes associated to Brugada Syndrome (BrS)
Abstract Brugada syndrome (BrS) is a rare cardiac arrhythmic disorder with high risk of sudden cardiac death. Recent advances have identified more than 20 risk loci with complex inheritance suggesting a polygenic model for BrS inheritance. These loci are in non-coding regions located in the vicinity of cardiac-expressed genes.
Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility | Nature Genetics
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Correction to: Nature Genetics https://doi.org/10.1038/s41588-021-01007-6, published online 24 February 2022. In the version of this article initially published, Federico Manevy’s name appeared with a middle initial in error. The name has been corrected in the HTML and PDF versions of the article. Author information Author notes These authors contributed equally: Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang, Mariam Jouni, Floriane Simonet, Vincent Probst, Arthur A.
By Rafik Tadros, David Chiang, Sean J. Jurgens, Roddy Walsh, Seung Hoan Choi, Arie O. Verkerk, Daniela Giachino, Oscar Campuzano, Óscar Paz Campuzano, Arnaud Bisson, Hector Barajas-Martinez, Martina Müller-Nurasyid, Jan H. Veldink, Philip Van Damme, Estelle Baron, Simon Lecointe, Jeroen Breckpot, Carlo de Asmundis, Elena Arbelo, Maria Molina, Peter Schwartz, Elijah Behr, Patrick T. Ellinor, Steven A. Lubitz, Michael W. Tanck, Paul W. Burridge, Christian Dina, Jean-Jacques Schott, Connie R. Bezzina, Julien Barc, Michele Nicastro, Cristina Gil Ortuño, Britt-Maria Beckmann, KORA-Study Group, Stéphane Bézieau, Carlo Napolitano, Pascal P. McKeown
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Contact Julien, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack