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Seung Hoan Choi on Muck Rack

Seung Hoan Choi

As seen in: Nature, BioRxiv, Cell Press, The American Journal of Human Genetics, medRxiv, Texas Medical Center, JACC (Journal of the American College of Cardiology)
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Articles

Sequencing in Over 50,000 Cases Identifies Coding and Structural Variation Underlying Atrial Fibrillation Risk

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By Seung Hoan Choi
| Texas Medical Center
Faculty, Staff and Student Publications Publication Date 3-1-2025 DOI 10.1038/s41588-025-02074-9 PubMedCentral® Posted Date 8-8-2026 PubMedCentral® Full Text Version Author MSS Abstract Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that included 52,416 AF cases and 277,762 controls.
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Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations

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By Satoshi Koyama, Zhi Yu, Seung Hoan Choi, Sean J. Jurgens, Margaret Sunitha Selvaraj, Derek Klarin, Jennifer Huffman Verified, Shoa L. Clarke, Selena Zhang, Michael N. Trinh, Akshaya Ravi, Jacqueline S. Dron, Catherine Spinks, Ida L. Surakka, Aarushi Bhatnagar, Kim Lannery, Whitney E. Hornsby, Scott M. Damrauer, Kyong-Mi Chang, Julie Lynch, Themistocles L. Assimes, Philip S. Tsao, Daniel Rader, Kelly Kasulis Cho, Gina M. Peloso, Patrick T. Ellinor, Yan Sun, Peter Wilson, Pradeep Natarajan
| Nature Verified
Abstract Rare coding alleles have crucial roles in the molecular diagnosis of genetic diseases. However, the systematic identification of these alleles has been challenging due to their scarcity in the general population. Here we discovered and characterized rare coding alleles contributing to genetic dyslipidemia, a principal risk for coronary artery disease (CAD), among 1,158,017 multi-ancestral individuals.
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Multiple-testing corrections in case-control studies using identity-by-descent segments

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By Seth D Temple, Nicola Chapman, Seung Hoan Choi, Anita DeStefano, Timothy Thornton, Ellen M. Wijsman, Elizabeth Blue
| The American Journal of Human Genetics Verified
Keywords multiple testing binary traits Alzheimer disease identity by descent haplotypes mean-reverting processes Introduction Population-based identity-by-descent (IBD) mapping complements a single-variant genome-wide association study (GWAS), which is better suited for common variant associations.1,2 GWASs and family-based studies have limited power to detect risk or causal variants that are recent and rare, particularly when those variants are observed in separate families.3 IBD mapping...
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