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Julio Saez-Rodriguez on Muck Rack

Julio Saez-Rodriguez

As seen in: Nature, PLOS, BMC Systems Biology, Genome Biology, Genome Medicine, Science Magazine, BioRxiv, Cell Press, Cell Systems, eLife and
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Articles

TROP2 targeting reveals therapy-driven cell state dynamics in colorectal cancer

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By Nuria Vaquero-Siguero, Maria C. Puschhof, Ioannis Chiotakakos, Jasmin Meier, Sigrid K Fey, Guillaume Belthier, Julia Volk, Carolin Artmann, Bryce Lim, Ronald Koschny, Cyrill Wehling, Kyanna Ouyang, Michael Gunther, Solveig Kuss, Moritz Mall, Jens Neumann, Steffen Ormanns, Thomas Schmidt, Jens Puschhof, Andreas Trumpp, Jacco van Rheenen, Julio Saez-Rodriguez, Rene Jackstadt, Nikolaos Georgakopoulos, Gabriele Diamante, Manuel Mastel, Aitana Guiseris-Martinez, Nikolai Schleußner, Paula Hoffmeister, Bruno C. Köhler
| Nature Verified
Abstract Metastasis remains the leading cause of cancer-related mortality and is driven by pronounced tumour cell plasticity1. Here we identify the transmembrane glycoprotein trophoblast cell-surface antigen 2 (TROP2) as a marker of poor-prognosis colorectal cancer (CRC) associated with WNTlow, fetal-like tumour cell states that are linked to metastasis and therapy resistance.
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Benchmarking EGF signaling pathway inference using phosphoproteomics and kinase-substrate interactions - Nature Communications

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By Martin Garrido-Rodriguez, Clement M Potel, Mira Lea Burtscher, Isabelle Becher, Pablo Rodriguez-Mier, Sophia Müller-Dott, Mikhail M. Savitski, Julio Saez-Rodriguez
| Nature Verified
Abstract Signaling pathways are useful models for interpreting molecular data, but their coverage has long been constrained by classic biochemistry methods. The growing corpus of kinase-substrate interactions, coupled to phosphoproteomics improvements, pave the way to revisit classic signaling pathways. In this study, we explore context-specific signaling pathway inference from phosphoproteomics and kinase-substrate networks.
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Publisher Correction: Interpretable inflammation landscape of circulating immune cells - Nature Medicine

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By Laura Jiménez-Gracia, Francesco Craighero, Maria Boulougouri, Ana M. Corraliza, Martin Banchero, Azucena Salas, José Manuel Carrascosa, Antonio Fernández Nebro, Juan D Cañete, Britta Siegmund, Antonio Julià, Violeta Serra, Sabine Tejpar, Martijn C. Nawijn, Ivo Gut, Julio Saez-Rodriguez, Alexandra-Chloé Villani, Juan Nieto Verified
| Nature Verified
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-04126-3, published online 12 January 2026. In the version of this article initially published, in the y-axis heatmap labels of Fig. 2a, “CD” originally was written as “RA”. This has now been corrected in the HTML and PDF versions of the article.
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