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Articles by Audrey Romano
Remodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation
Keywords macrophages osteoclasts neuroinflammation LCMV skull channels skull-marrow skull-meninges connections meningitis Get full text access Log in, subscribe or purchase for full access. References 1. Rua, R. ∙ McGavern, D.B. Advances in meningeal immunity Trends Mol. Med. 2018; 24:542-559 2. Brioschi, S. ∙ Wang, W.-L. ∙ Peng, V. ... Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders Science. 2021; 373, eabf9277 3. Cugurra, A. ∙ Mamuladze, T. ∙ Rustenhoven, J. ...
3′Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosine
Summary Background Miltefosine treatment failure in visceral leishmaniasis in Brazil has been associated with deletion of the miltefosine susceptibility locus (MSL) in Leishmania infantum. The MSL comprises four genes, 3′-nucleotidase/nucleases (NUC1 and NUC2); helicase-like protein (HLP); and 3,2-trans-enoyl-CoA isomerase (TEI). Methods In this study CRISPR-Cas9 was used to either epitope tag or delete NUC1, NUC2, HLP and TEI, to investigate their role in miltefosine resistance mechanisms.
Sites Upgrade Complete!
The Sites Upgrade is now complete and full access has been restored. Users now have access to 300+ themes and 70+ plugins, including the new Divi for PSU theme. Upgraded plugin functionality includes the ability to embed any document, create footnotes, add help and support pages, use Google web fonts, create tables of contents, bring zotero to your site, add the Divi Builder to any theme, and much much more! A few existing plug-ins were migrated to new counterparts.
August 15th Upgrade Nearly Complete
It appears that DNS is now working. We will continue to monitor the issue and update this alert as necessary. We apologize for any delays during the upgrade this morning. Please note that more information will be provided in the ITS Alert: http://alerts.its.psu.edu/alert-4173 Thank you for you patience and understanding throughout this process. If you have any questions or concerns, please contact sites@psu.edu
Reminder, Read-only mode starts Today, Friday August 12th at 6pm
As a reminder, Sites at Penn State will be upgrading this weekend starting at 6 p.m. ET TODAY, Friday, August 12th. As of that time, Sites will go into read-only mode, locking editing abilities. All sites will remain available to for viewing. Access will be restored by 8 a.m. ET on Monday, August 15th. For more details about this upgrade, please visit: http://sites.psu.edu/blog/2016/08/01/upgrade-to-impact-sites-on-august-12-15/
Important Changes regarding FPS accounts
As you may know, we are in the process of upgrading the Sites at Penn State service. Our team has been working very hard to make sure this transition has minimal impact on our customers, however after careful review of service support capabilities, Friends of Penn State (FPS) accounts will no longer be supported by Sites at Penn State on August 12th. If your site has been identified as having one or more FPS accounts associated with it, you will have received this notice in email.
Important Changes regarding ANGEL LTI usage on the Sites at Penn State service
If you were part of the ANGEL LTI pilot please be aware that the upcoming upgrades to the Sites at Penn State service infrastructure will no longer be able to support the ANGEL LTI pilot as of August 12th. Users that already have access to your course blog(s) will not be altered or removed. This will only effect new user access. Thank you for your participation in this pilot program. We hope to develop a Canvas LTI to replace this functionality in the future.
Upgrade to impact Sites on August 12-15; Read-only mode
Sites at Penn State will be upgrading the service in order to expand theme and plug-in capabilities. At 6 p.m. ET on August 12th, Sites will go into read-only mode, locking editing abilities. Please note, all sites will remain available to for viewing. Access will be restored by 8 a.m. ET on August 15th. New features available after migration include, more than 400 new themes and 50-plus new plugins, including a new Divi for Penn State theme.
IFN-gamma mediated inflammatory monocyte recruitment neutralizes iNOS-dependent parasite killing by expanding the permissive host cell reservoir during early Leishmania amazonensis infection
IFN-γ is a key factor in the elimination of intracellular parasites. However, during early L. amazonensis infection IFN-γ production does not correlate with a reduction in parasite growth and IFN-γ−/− mice do not have enhanced parasite loads. The reason why IFN-γ production does not reduce parasite loads during early L.a. infection is controversial.
Exciting changes are in store for Sites at Penn State!
Exciting changes are in store for Sites at Penn State! Throughout August, you can expect to see a multitude of new plugins and themes available to the Penn State community. To prepare for these upgrades, the Sites team will be doing some spring cleaning starting April 25 and will continue through August. This will include retiring abandoned sites (those with no Admin/Owners or have not been updated since creation for at least 4 months) as well as a few outdated and unsupported plugins and themes.
Users Group Meet-up - Friday, February 12!
This Friday, February 12th is the next Sites Users Group Meet-up. Each meeting is scheduled from 11am to noon at the TLT Studio located in The 300 Building, West College Avenue (across from Noodles & Company) or virtually via Google Hangout. The first part of the meetup will be a quick intro to some of the latest additions/improvements made to the service and what’s coming up next.
Email Confirmations for New Site Creations
The Sites at Penn State team has put into effect a temporary, performance-enhancing system to help handle the increased demand on the service at the beginning of a new semester. When you create a new site, you will receive an email confirmation to your Penn State email address shortly after you create a new website. It will contain a link to your new site once your new website has been successfully created.
Users Group Meet-up - Friday, January 8!
This Friday, January 8th is the next Sites Users Group Meet-up. Each meeting is scheduled from 11am to noon at the TLT Studio located in The 300 Building, West College Avenue (across from Noodles & Company) or virtually via Google Hangout. We don’t have any major updates to showcase since coming back from Winter Break, but we will be around to discuss anything relating to the platform — suggestions, issues, demos, etc. If you plan on attending please let us know by following out the following form.
New Penn State Mark update for Genesis for PSU and TwentyTwelve for PSU
It’s that moment you’ve been waiting for! The Penn State themes, Genesis for PSU and TwentyTwelve for PSU, will be updating automatically within the week to display the new Penn State mark. The themes conform to all visual standards and guidelines as per the Department of University Marketing and have been approved by ITS Marketing and Communications. The update should not affect the content of your website, only the header region, featuring the mark and site title, and the footer.
Cancelled: User Group Meetup for Friday, Dec. 11
There will be no Sites User Group Meetup for December due to it being the last day of classes and the week before finals. However, we will resume the Meetups after winter break, so mark your calendars for Friday, January 8th! We’ll post a sign up form when we get closer to the date.
Users Group Meet-up - Friday, November 13!
This Friday, November 13th is the next Sites Users Group Meet-up. Each meeting is scheduled from 11am to noon at the TLT Studio located in The 300 Building, West College Avenue or virtually via Google Hangout. The first part of the meetup will be a quick intro to some of the latest additions/improvements made to the service and what’s coming up next. We follow with free-form discussion, giving you all the opportunity to discuss anything relating to the platform — suggestions, issues, demos, etc.
Cancelled: User Group Meetup for Friday, Oct. 9
There will be no Sites User Group Meetup this Friday, Oct. 9. However, stay tuned for the next month’s meetup and mark your calendars for Friday, November 13th!
Introducing a New Design for Sites
Please join us in welcoming a new look for the Sites at Penn State landing page. We’ve worked to make the landing page for Sites more informative for all of our users. We now have an Updates blog where we will post about new features the team adds to the service and other announcements.
Users Group Meet-up - Friday, August 14!
Hey all! It’s that time again! Friday, August 14th is the next Sites Users Group Meet-up, and every 2nd Friday of the month henceforth. Mark your calendars! Each meeting is scheduled from 11am to noon at the TLT Studio located in The 300 Building, West College Avenue. The first part of the meetup will be a quick intro to some of the latest additions/improvements made to the service and what’s coming up next.
Introducing Reader: A New Way to Follow and Search Blogs and Sites
Last week you may have noticed a new link titled, 📘 Reader, in the admin bar at the top of your Sites Dashboard. Reader turns the Sites at Penn State network into a community by adding Tumblr and WordPress.com -style “❤️ Follow” features. Also, if you are an instructor who currently uses the Tag Search (aka Penn State Voices), Reader is the replacement for this tool. Follow Your Favorites Reader adds a “Follow” button to the admin bar on every site in the Sites at Penn State network.
Updates: Divi Theme
Divi is a new drag-and-drop theme that is highly configurable, allowing you to build and save any number of page templates. There are even 20+ pre-made page layouts you can choose from to get started quickly and then customize to your preferences. You can view the full theme demo and reference the setup documentation when you’re ready to give it a try. We think it’s really great for those of you building complex websites, such as for departments and organizations.
Users Group Meet-up - Friday, July 10!
Starting Friday, July 10, we will be hosting a Sites Users Group Meet-up every 2nd Friday of the month. Mark your calendars! Each meeting is scheduled from 11am to noon at the TLT Studio located in The 300 Building, West College Avenue. The first part of the meetup will be a quick intro to some of the latest additions/improvements made to the service and what’s coming up next.
Updates: WordPress 4.2 and more!
WordPress Version 4.2.2 update New features include: Extended character support including native Chinese, Japanese, and Korean characters, musical and mathematical symbols, hieroglyphs, and emoji! 🌟 🎉 👍 We’ve carefully upgraded every site behind the scenes so that you can use this new feature. Switch themes in the Customizer – preview new themes with ease! Tumblr and Kickstarter embedding.
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