Audrey Romano

Keywords macrophages osteoclasts neuroinflammation LCMV skull channels skull-marrow skull-meninges connections meningitis Get full text access Log in, subscribe or purchase for full access. References 1. Rua, R. ∙ McGavern, D.B. Advances in meningeal immunity Trends Mol. Med. 2018; 24:542-559 2. Brioschi, S. ∙ Wang, W.-L. ∙ Peng, V. ... Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders Science. 2021; 373, eabf9277 3. Cugurra, A. ∙ Mamuladze, T. ∙ Rustenhoven, J. ...

Summary Background Miltefosine treatment failure in visceral leishmaniasis in Brazil has been associated with deletion of the miltefosine susceptibility locus (MSL) in Leishmania infantum. The MSL comprises four genes, 3′-nucleotidase/nucleases (NUC1 and NUC2); helicase-like protein (HLP); and 3,2-trans-enoyl-CoA isomerase (TEI). Methods In this study CRISPR-Cas9 was used to either epitope tag or delete NUC1, NUC2, HLP and TEI, to investigate their role in miltefosine resistance mechanisms.

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