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Articles by Jun Ouyang
Developing analysis algorithm for engineered skeletal muscle contractile function based on a microphysiological system
Abstract Autonomous contractility is a key functional characteristic of skeletal muscle and an important indicator of engineered muscle maturation. Conventional contact-based force measurements are limited by mechanical interference, restricted spatial resolution, and poor compatibility with high-throughput microphysiological systems. Here, we present a non-contact optical–mechanical framework for quantitative evaluation of contractile dynamics in three-dimensional engineered skeletal muscle.
A Trojan horse nanoplatform overcoming delivery barriers for targeted gene immunotherapy of colorectal cancer
Abstract Programmed cell death ligand 1 (PD-L1) antibody has been shown to hold tremendous promise in curing metastatic colorectal cancer (CRC). However, the delivery efficacy of the targeted biologics limits this immunotherapy in a subset of CRC. Here we report a novel biomimetic ‘Trojan horse’ nano-delivery system for targeted gene-immunotherapy of colorectal cancer.
Large Transverse Piezoelectricity in Highly (001)-Oriented PZT Thick Films on Titanium Substrates
You are already at the latest version Integration of lead zirconate titanate (PZT) films on metallic substrates is important for flexible piezoelectric devices, but achieving highly textured crystallinity without detrimental interfacial diffusion or oxidation remains challenging. In this work, PZT thick films (~1.3 μm) were deposited on titanium substrates using radio-frequency magnetron sputtering at 400 °C followed by rapid thermal processing at 640 °C for 2.5 min.
AI-assisted quantitative analysis for evaluating melanin distribution in 3D pigmented epidermis-on-a-chip models
Abstract Introduction: Abnormal pigmentation plays an important role in various skin diseases and in studies of whitening efficacy.Three-dimensional pigmented epidermis-on-a-chip models provide a crucial in vitro platform for exploring melanin production and regulation in skin. However, dynamic and non-invasive quantitative assessment of melanin distribution remains difficult with traditional histological methods.
Dual-sensor coherence-driven adaptive denoising (WF-VMD-DDCDO) for underwater target detection
Abstract Underwater vehicle will generate a shaft-rate magnetic field at the propeller rotation frequency as the fundamental frequency during navigation, hence offering a approach for underwater target detection. Conventional shaft-rate magnetic field detection algorithms presume that the signal noise is Gaussian white noise. Moreover, the interference line spectrum frequently manifests, significantly elevating the false alarm rate in shaft-rate magnetic field detection.
Unraveling the metabolic‒epigenetic nexus: a new frontier in cardiovascular disease treatment - Cell Death & Disease
Abstract Cardiovascular diseases are the leading causes of death worldwide. However, there are still shortcomings in the currently employed treatment methods for these diseases. Therefore, exploring the molecular mechanisms underlying cardiovascular diseases is an important avenue for developing new treatment strategies. Previous studies have confirmed that metabolic and epigenetic alterations are often involved in cardiovascular diseases across patients.
Framing of Differences: Visual Product Frames Reduce Consumer Choice Deferrals
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C(sp3)–H Carbonylative Cyclization of Hydrazones with CO2: Synthesis of Pyrazolone Derivatives
The Journal of Organic Chemistry Cite this: J. Org. Chem. 2024, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Uric acid mediates kidney tubular inflammation through the LDHA/ROS/NLRP3 pathway
ABSTRACT Purpose Hyperuricemia (HUA) is an important factor leading to chronic kidney disease (CKD). The kidney tubular inflammatory response is activated in HUA. This study aimed to investigate whether lactate dehydrogenase A (LDHA) is involved in mediating uric acid-induced kidney tubular inflammatory response. Methods In vivo, an HUA mouse model was established by continuous intraperitoneal injection of potassium oxonate (PO) for one week.
Current Gallstone Treatment Methods, State of the Art
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High performance LaNiO3-buffered, (001)-oriented PZT piezoelectric films integrated on (111) Si
Lead zirconate titanate [Pb(Zrx,Ti1-xO3) or PZT] materials have shown many superb electrical properties, including a large ferroelectric polarization, high dielectric constants, and outstanding piezoelectric performances.1–31. P. Muralt, M. Kohli, T. Maeder et al., “ Fabrication and characterization of PZT thin-film vibrators for micromotors,” Sens. Actuators, A 48, 157–165 (1995). https://doi.org/10.1016/0924-4247(95)00994-92. A. Dalakoti, A. Bandyopadhyay, and S.
Last deglacial and Holocene vegetation evolution and climate variability in the subalpine western Nanling Mountains in South China
Pollen analysis of a 236-cm-long core at Daping Swamp, a subalpine swamp in the western Nanling Mountains, provided a history of vegetation evolution that was related to climate changes in the last 15,400 years. Generally, pollen data revealed a subtropical climate in the past 15,400 years. In the last deglacial period (15,400–10,900 cal yr BP), the study region was characterized by evergreen and deciduous broadleaved forests.
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