Yingying Wang
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Shape Transformation of Ternary PtIrPd Nanocrystals with High-Index Facets via Electrodeposition and Study of Their Catalytic Activity in Alcohol Oxidation Reactions Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! The catalytic activities of Pt-based nanomaterials strongly depend on their structures, including their compositions, arrangements of surface atoms, and so on. Shape-controlled synthesis has proven to be an efficient route to adjust the surface structure, while alloying has been considered an effective strategy to tune the electronic structure.
Pleurotin Total Synthesis: Legacy Route and Recent Progress
, , , Pleurotin Total Synthesis: Legacy Route and Recent Progress, European Journal of Organic Chemistry2026, 0, e70648. https://doi.org/10.1002/ejoc.70648 Acknowledgments This work was supported by the National Undergraduate Training Program for Innovation and Entrepreneurship (202310285073Z, 202110285051Z), State Key Laboratory of Natural and Biomimetic Drugs (K202425), National Natural Science Foundation of China (81903442). Conflicts of Interest The authors declare no conflicts of interest.
TRMT1-mediated tRNA m 2 2 G modification drives Osimertinib resistance via the ATXN3/USP25 axis in lung adenocarcinoma
Abstract Acquired resistance to Osimertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), remains a critical challenge in lung adenocarcinoma. Here, we identify ATXN3, a deubiquitinating enzyme, as a driver of Osimertinib resistance and a predictor of poor patient survival. Osimertinib treatment dynamically upregulates ATXN3 transcription, which stabilizes USP25 through deubiquitination, activating an ATXN3-USP25-TRMT1 signaling cascade.
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