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Articles by Junfeng Hao
World Models: Predictive State, Generative Simulation, and Decision-Making Across Artificial Intelligence
Submitted: 07 September 2026 Posted: 08 September 2026 You are already at the latest version World model has become an umbrella term for systems with very different scientific obligations. A recurrent latent con-troller, a diffusion environment, a four-dimensional driving simulator, a symbolic transition model, and a neural weatherforecaster can all predict futures, yet they expose different state, control, and uncertainty interfaces.
Benchmark, Agent, and Tool-Use Harnesses for Large Language Models: A Taxonomy of Evaluation Infrastructure
Submitted: 01 September 2026 Posted: 03 September 2026 You are already at the latest version Large language model evaluation has moved from static benchmark scripts to executable harnesses:systems that bind datasets, prompts, model adapters, inference backends, tools, environments, sandboxes,scorers, traces, and leaderboards into a measurement contract. This survey explains why that layer nowdetermines what a benchmark score means. We distinguish three harness families.
Spiking Neural Networks from Signals to Silicon:An End-to-End Survey of Dynamics, Learning,Architectures, Toolchains, Neuromorphic Hardware,and Deployment
Submitted: 01 September 2026 Posted: 02 September 2026 You are already at the latest version Spiking neural networks (SNNs) are often intro-duced as neural networks with binary activations and temporalstate. That description omits the engineering contracts that deter-mine whether spikes remain useful after training and deployment.This survey follows an SNN from physical signal to actionableoutput.
Application of widely targeted metabolomics combined with network pharmacology and molecular docking to elucidate growth stage-specific metabolite accumulation and predict the diuretic mechanisms of Leontopodium leontopodioides (Willd.) Beauv
Abstract Leontopodium leontopodioides (Wild.) Beauv. (LLB) was investigated to determine its metabolite profiles and bioactivities across different growth stages. Ultrasound-assisted extraction was employed to obtain total flavonoids and phenolic acids from LLB samples collected at the vegetative and reproductive stages, and their in vitro antioxidant capacities were then evaluated. UHPLC-MS/MS-based metabolomics was subsequently used to compare the metabolite changes between the two growth stages.
Computer Science > Computation and Language
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Sirp-α Monoclonal Antibody Reduces Tumor Migration and Invasion by Di
Junfeng Hao,1,2,* Naiquan Liu,3,* Xin Huang,1,* Hanlei Zhou,3 Hanrong Li,4 Yizhou Zhang,4 Bing Yu,5 Ziqian Bi,6 Xinyuan Song,7 Shunan Li,8 Keyu Chen,9 Ning Li,10 Chao Zhu,11 Jiahe Wang1 1Department of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China; 2Department of Nephrology, and Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University,...
[2502.03974] Spatiotemporal Trajectory Tracking Method for Vehicles Incorporating Lead-Lag Judgement
Construction of a C-reactive protein-albumin-lymphocyte index-based prediction model for all-cause mortality in patients on maintenance hemodialysis
Abstract Objective The mortality rate of patients undergoing maintenance hemodialysis (MHD) remains high. The C-reactive protein-albumin-lymphocyte (CALLY) index is a novel biomarker that reflects inflammation, nutritional and immune status, all merged into one single derived parameter. No study has yet linked the CALLY index to survival in hemodialysis.
From the regulatory mechanism of TFEB to its therapeutic implications - Cell Death Discovery
Abstract Transcription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by binding to coordinated lysosomal expression and regulation (CLEAR) elements. TFEB are regulated by multiple links, such as transcriptional regulation, post-transcriptional regulation, translational-level regulation, post-translational modification (PTM), and nuclear competitive regulation.
Mitochondrial metabolism and targeted treatment strategies in ischemic-induced acute kidney injury - Cell Death Discovery
Abstract Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI). The kidney is susceptible to IRI under several clinical conditions, including hypotension, sepsis, and surgical procedures, such as partial nephrectomy and kidney transplantation.
Effects of Different Temperature and Density on Quality and Microbial Population of Alfalfa Silage
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 8 January 2024 / Approved: 8 January 2024 / Online: 9 January 2024 (02:51:31 CET) Liu, J.; Hao, J.; Zhao, M.; Yan, X.; Ge, G. Effects of Different Temperature and Density on Quality and Microbial Population of Alfalfa Silage. Preprints 2024, 2024010634. https://doi.org/10.20944/preprints202401.0634.v1 Liu, J.; Hao, J.; Zhao, M.; Yan, X.; Ge, G.
An IGFBP7hi endothelial cell subset drives T cell extravasation in psoriasis via endothelial glycocalyx degradation
Open Access | Research Article Inflammation Vascular biology 10.1172/JCI160451 Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Address correspondence to: Gang Wang or Erle Dang, Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 127 Changlexi Road, Xi'an, Shaanxi, China. Phone: 86.29.18629352992; Email: wanggangxjyy@163.com (GW).
Optimization of Extraction Process and Dynamic Changes in Triterpenoids of Lactuca indica from Different Medicinal Parts and Growth Periods
Abstract : In this study, the triterpenoids in the leaves of Lactuca indica L.cv. Mengzao (LIM) were extracted via microwave-assisted ethanol extraction, and the optimum extraction conditions for triterpenoids were determined through single-factor experiments and the Box–Behnken method. The effects of three factors (solid–liquid ratio, microwave power and extraction time) on the total triterpenoids content (TTC) were evaluated.
Combination treatment with FAAH inhibitors/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway | Cell Death & Disease
Abstract Ferroptosis, a nonapoptotic form of programmed cell death characterized by significant iron-dependent peroxidation of phospholipids, is regulated by cellular metabolism, redox homeostasis, and various cancer-related signaling pathways. Recently, considerable progress has been made in demonstrating the critical role of lipid metabolism in regulating ferroptosis, indicating the potential of combinational strategies for treating cancer in the future.
Accelerated tumor metastasis due to IFNγ receptor-mediated dissociation of perivascular cells from blood vessels
Angiostasis mediated by IFN? is a key mechanism of anti-tumor immunity; however, the effect of IFN? on host VEGFA-expressing cells during tumor progression is still elusive. Here, we developed transgenic mice with IFN? receptor (IFN?R) expression under control of the Vegfa promoter (V-?R). In these mice, the IFN? responsiveness of VEGFA -expressing cells led to a dramatic growth suppression of transplanted lung carcinoma cells.
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