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Articles by Junfeng Ma
Paired pre- and post-transplant human immunoprofiling identifies an IFN-γ-JAK1 axis limiting stem-cell-derived RPE engraftment
Keywords stem cell transplantation immune microenvironment age-related macular degeneration translational medicine retinal regeneration cell therapy graft immunogenicity immune rejection transplant immunology JAK-STAT signaling Get full text access Log in, subscribe or purchase for full access. References 1. Jin, Z.-B. ∙ Gao, M.-L. ∙ Deng, W.-L. ... Stemming retinal regeneration with pluripotent stem cells Prog. Retin. Eye Res. 2019; 69:38-56 2. Lim, L.S. ∙ Mitchell, P. ∙ Seddon, J.M. ...
Cancer-associated adipomes promote invadopodia formation and enhance metastatic potential in triple-negative breast cancer
Abstract Triple-Negative Breast Cancer (TNBC), which accounts for 15–20% of all breast cancer cases, remains one of the most aggressive and therapeutically challenging subtypes due to its lack of hormone receptors and HER2 expression, leaving chemotherapy as the primary treatment option. TNBC is characterized by early relapses and visceral metastasis, underscoring the urgent need to elucidate the mechanisms driving metastasis.
Author Correction: O -GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer
Correction to: Nature Communications https://doi.org/10.1038/s41467-024-49875-w, published online 03 July 2024 In the version of this article initially published, the palbociclib image in Fig. 2k was an inadvertent duplicate of the palbociclib image in Fig. 2j. Source data containing the original, uncropped images used to generate the figure are available (https://doi.org/10.6084/m9.figshare.31356262). The figure has been updated in the HTML and PDF versions of the article.
The unphosphorylated, closed form of ezrin binds to RNA to maintain a metastatic phenotype in osteosarcoma cells
Editor’s summary When phosphorylated, the protein ezrin adopts an open conformation and translocates to the plasma membrane, where it forms scaffolds that regulate cell shape, polarity, and adhesion. Unphosphorylated ezrin is in a closed conformation and considered inactive. However, Deniz et al.
Cracking the code to O-GlcNAcylation networks - Nature Chemical Biology
Understanding protein glycosylation is essential to decode complex cellular networks. A systems-level approach that networks substrate and interacting proteins of O-GlcNAc transferase, the sole enzyme catalyzing O-GlcNAcylation on thousands of proteins, provides insights into the functional relationship of O-GlcNAcylation and coordinated cellular signaling networks.
Sweet spots of O-glucosylation - Nature Chemical Biology
Chemical biology tools are critical to provide new insights into glycobiology. A protein O-glycosyltransferase, Legionella translocated protein M (LtpM), is reported as a glycoengineering tool that requires strict and short consensus sequons to probe β-O-glucosylation and O-GlcNAcylation.
Oat β-Glucooligosaccharides: Preparation, characterization, skin permeability, and photodamage repair for skincare applications
Introduction Polysaccharides have been extensively utilized in skincare formulations for decades, valued primarily for their moisturizing properties. The structural diversity of sugar units—including variations in glycosidic linkages, chain conformation, and spatial configuration—enables polysaccharides exhibit unique biological functions.
Design and optimisation of green closed-loop supply chain network considering additional selling agents and multilevel customers: a SME case study
Abstract Small- and medium-sized enterprises (SMEs) are crucial to economic development, yet they face challenges in enhancing supply chain (SC) performance while addressing environmental concerns. This study develops a green closed-loop supply chain (CLSC) model that integrates economic, environmental and operational objectives to support SME decision-making. The model introduces a reselling market to boost profitability by incorporating product reuse in reverse logistics for secondary customers.
A ROS-mediated oxidation-O-GlcNAcylation cascade governs ferroptosis - Nature Cell Biology
Abstract Reactive oxygen species (ROS) play a crucial role in lipid peroxidation and the initiation of ferroptosis, markedly affecting chemotherapeutic drug resistance. However, the mechanisms by which ROS function and are sensed remain poorly understood. In this study, we identified O-GlcNAc transferase (OGT), a key enzyme in protein O-GlcNAcylation, as a sensor for ROS during ferroptosis. The ROS-induced oxidation of OGT at C845 in its catalytic domain activates the enzyme.
Exploring the Increased Activity of the Blue Light-Dependent Photoenzyme Fatty Acid Photodecarboxylase under Violet Light
Introduction Click to copy section linkSection link copied! Light-driven enzymatic reactions provide a versatile and chemically diverse approach to the production of chemicals and fuels. However, photoenzymes are rarely found in nature. (1) Fatty acid photodecarboxylase from Chlorella variabilis (CvFAP) is the most recently discovered naturally occurring photoenzyme, the only other two being DNA photolyase and protochlorophyllide oxidoreductase.
Advances in Antimicrobial Peptides: Mechanisms, Design Innovations, and Biomedical Potential
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary Influenza
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Hydrothermal Synthesis of Hierarchical Cage-like Co9S8 Microspheres Composed of Nanosheets as High-Capacity Anode Materials
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A superelastic and ultralight graphene aerogel with a hydrophobic honeycombed structure for efficient absorption of hazardous organics
A superelastic and ultralight graphene aerogel with a hydrophobic honeycombed structure for efficient absorption of hazardous organics Environmentally friendly graphene-based aerogels have been utilized to recycle leaked organic solvents that pose a threat to the ecological environment.
O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer - Nature Communications
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhibitors (CDK4/6i), such as palbociclib, remains a substantial challenge in clinical settings.
Integrating Embeddings from Multiple Protein Language Models to Improve Protein O-GlcNAc Site Prediction
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Direct stimulation of de novo nucleotide synthesis by O-GlcNAcylation - Nature Chemical Biology
Mice Experiments involving animals adhered to a protocol with approval from Institutional Animal Care and Use Committee (IACUC) at Georgetown University. The animals were accommodated in well-ventilated cages with regulated temperature between 20 °C and 26 °C, with humidity levels within the range of 30–70%, with a 12-h light/dark cycle and having unrestricted access to food and water. No more than five mice lived in one cage.
Resistance to abemaciclib is associated with increased metastatic potential and lysosomal protein deregulation in breast cancer cells
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Application of Caenorhabditis elegans in Lipid Metabolism Research
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Lu An , Xueqi Fu , Jing Chen * and Junfeng Ma * National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China * Authors to whom correspondence should be addressed. Int. J. Mol. Sci.
In Situ Solidified Gel Polymer Electrolytes for Stable Solid−State Lithium Batteries at High Temperatures
Open AccessArticle by Junfeng Ma 1,2, Zhiyan Wang 2, Jinghua Wu 2, Zhi Gu 2, Xing Xin 1 and Xiayin Yao 2,3,* 1 School of Material Science and Chemical Engineering, Ningbo University, Ningbo 315211, China 2 Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China 3 Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China * Author to whom correspondence should be addressed.
Life cycle assessment comparison of wooden and plastic pallets in the grocery industry
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Efficacy Investigation of Virtual Reality Teaching Module in Manufacturing System Design Course
Gershwin, S. , 1993, Manufacturing Systems Analysis, Prentice Hall, Upper Saddle River, NJ. Prinard-Welyczko, K. M., Garrison, A. C. S., Ramos, R. L., and Cater, B. S., 2017, “ Characterizing the Undergraduate Neuroscience Major in the U.S.: An Examination of Course Requirements and Institution-Program Associations,” J. Undergrad. Neurosci. Educ., 16(1), pp. A60–A67. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777840/ Mostafa, S. , Dumrak, J. , and Soltan, H.
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