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Articles by Junhui Chen
Time-resolved transcriptomic and proteomic profiling of cisplatin-induced nephrotoxicity in mouse models
Abstract Kidney disease represents a significant clinical challenge, with incidence and mortality rising despite therapeutic advances such as dialysis and transplantation. Among its multifactorial causes, drug-induced nephrotoxicity, particularly from cisplatin, a widely used chemotherapeutic agent, represents a frequent and dose-limiting complication that can trigger both acute injury and progressive damage to the kidney.
Establishment of a scalable engineered cell-line platform for direct, GMP-grade production of eVLP vectors enabling streamlined generation of gene-edited CAR-T/NK cells
Abstract Introduction: CRISPR–Cas9 has transformed the engineering of chimeric antigen receptor T (CAR-T) cells and chimeric antigen receptor NK (CAR-NK) cells; however, its clinical translation remains constrained by the high cost, batch-to-batch variability, and stringent regulatory requirements associated with current viral and electroporation-based manufacturing approaches.
Exploring leaf variegation in Arabidopsis yellow variegated2 by single‐cell RNA sequencing
Conflict of Interest The authors declare that they have no competing interests. DATA AVAILABILITY STATEMENT The raw sequence data has been deposited in the Genome Sequence Archive under the accession number of CRA007829 in the National Genomics Data Center, China National Center for Bioinformation/Beijing Institute of Genomics, Chinese Academy of Sciences (https://ngdc.cncb.ac.cn/gsa/browse/CRA007829). Analysis code can be obtained at https://github.com/Atvar2/var2-mutant.
Association between the neutrophil percentage-to-albumin ratio and pelvic adhesion severity in endometriosis: A retrospective cross-sectional study
Loading metrics Open Access Peer-reviewed Research Article Citation: Tan X, Zhang H, Yang C, Chen J (2025) Association between the neutrophil percentage-to-albumin ratio and pelvic adhesion severity in endometriosis: A retrospective cross-sectional study. PLoS One 20(12): e0337077. https://doi.org/10.1371/journal.pone.0337077 Editor: Athanasios G.
Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy
1 Introduction CDDP, a highly effective chemotherapy agent, is widely used in the treatment of various malignancies.[1, 2] The CDDP requires intracellular bioactivation, wherein chlorides are substituted by water molecules.[3] This activation process generates highly reactive species binding to DNA, inducing cytotoxic lesions within tumors.[4] However, the undesirable accumulation of CDDP may also provoke cytotoxic effects in healthy tissues.
Transcriptome profiling of tumor-infiltrating lymphocyte-mediated cytotoxicity against patient-derived lung cancer organoids - Communications Biology
Abstract Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality, and therapies utilizing tumor-infiltrating lymphocytes (TILs) show significant promise. However, molecular signatures defining a productive TIL-mediated response remain poorly characterized. Here, we establish a patient-derived organoid and autologous TIL co-culture platform to show that expanded TILs mediate potent, specific cytotoxicity against NSCLC organoids.
Transcriptome Analysis of Culex pipiens quinquefasciatus Larvae Exposed to a Semi-Lethal Dose of Vermistatin
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Neural Scoring: A Refreshed End-to-End Approach for Speaker Recognition in Complex Conditions
[Submitted on 21 Oct 2024 ( v1 ), last revised 3 Jul 2025 (this version, v3)] Title:Neural Scoring: A Refreshed End-to-End Approach for Speaker Recognition in Complex Conditions View a PDF of the paper titled Neural Scoring: A Refreshed End-to-End Approach for Speaker Recognition in Complex Conditions, by Wan Lin and Junhui Chen and Tianhao Wang and Zhenyu Zhou and Lantian Li and Dong Wang View PDF HTML (experimental) Abstract:Modern speaker verification systems primarily rely on speaker...
Isolation and Identification of Culturable Bacteria from South China Seawater and Preliminary Screening of Marine Biocontrol Bacteria
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Global trends in the burden of chronic kidney disease attributable to type 2 diabetes: An age‐period‐cohort analysis
Aim To assess temporal trends of chronic kidney disease (CKD) attributable to type 2 diabetes (T2D) globally and in five sociodemographic index (SDI) regions. Materials and Methods We extracted the population data and CKD burden attributable to T2D from the Global Burden of Disease Study 2019.
Talaromyces sp. Ethyl Acetate Crude Extract as Potential Mosquitocide to Control Culex pipiens quinquefasciatus
1. Introduction Mosquitoes are important vectors for transmitting a wide range of serious human and animal diseases (e.g., malaria, dengue), posing a threat to public health. Malaria killed more than 400,000 people in 2019 [1]. Culex pipiens quinquefasciatus, known as the ‘southern house mosquito’, is distributed throughout southern China. Cx. p.
[2305.16592] A Multi-Scale Attentive Transformer for Multi-Instrument Symbolic Music Generation
arXiv:2305.16592 (cs) Download a PDF of the paper titled A Multi-Scale Attentive Transformer for Multi-Instrument Symbolic Music Generation, by Xipin Wei and Junhui Chen and Zirui Zheng and Li Guo and Lantian Li and Dong Wang Download PDF Submission history From: Lantian Li Mr. [ view email] [v1] Fri, 26 May 2023 02:41:56 UTC (1,369 KB) Bibliographic Tools Bibliographic Explorer Toggle Bibliographic Explorer () Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle scite Smart Citations...
The Mosquito Larvicidal Activity of Lignans from Branches of Cinnamomum camphora chvar. Borneol
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Effects of the neurotoxin β-N-methylamino-L-alanine (BMAA) on the early embryonic development of marine shellfish and fish
1College of Environmental Science and Engineering, Ocean University of China, Qingdao, China 2Key Laboratory of Marine Environment and Ecology, Ocean University of China, Ministry of Education, Qingdao, China The neurotoxin β-N-methylamino-L-alanine (BMAA) produced by cyanobacteria and diatoms can accumulate in diverse aquatic organisms through the food web.
Clinically suspected lethal viral myocarditis combined with encephalitis: a COVID‐19 vaccine complication
Junhui Chen, Ting Wu, and Chunlei Zhang contributed equally. Abstract This case study aimed to identify rare viral myocarditis combined with encephalitis as a COVID-19 vaccine complication. A 59-year-old male patient with a 2 day history of headache and rapidly progressive cognitive decline, who had received the third dose of COVID-19 vaccine 12 days before, was admitted to our hospital.
Rational Molecular Design for Isoindigo-Based Polymer Semiconductors with High Ductility and High Electrical Performance
Rational Molecular Design for Isoindigo-Based Polymer Semiconductors with High Ductility and High Electrical Performance Achieving good electrical properties and ductility of polymer semiconductors has always been challenging. In this work, a series of isoindigo derivative-based conjugated polymers were studied in an effort to gain a better understanding of the influence of polymer main and side chain structures on their electrical and mechanical properties.
Histone Deacetylases (HDACs) Guided Novel Therapies for T-cell lymphomas
PDF Int J Med Sci 2019; 16(3):424-442. doi:10.7150/ijms.30154 Review Qing Zhang1 , Shaobin Wang2, Junhui Chen1, Zhendong Yu3 1. Department of Minimally Invasive Intervention, Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, China. 2. Health Management Center of Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, China. 3. China Central Laboratory of Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, China.
Improved Transistor Performance of Isoindigo-Based Conjugated Polymers by Chemically Blending Strongly Electron-Deficient Units with Low Content To Optimize Crystal Structure - Macromolecules (ACS Publications)
Conjugated polymers have received tremendous attention because of their potential application in flexible electronic devices. In addition to synthesizing new conjugated polymers, different methods have been used to improve charge carrier transport.
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