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Junitta B. Guzman

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Articles

Technical and biological sources of noise confound multiplexed enhancer AAV screening

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By Avery C. Hunker, John K. Mich, Naz Taskin, Amy Torkelson, Trangthanh Cardenas, Jean-Benoît Lalanne, Joseph Mahoney, Darren Bertagnolli, Anish Bhaswanth Chakka, Rushil Chakrabarty, Nicholas Donadio, Rebecca A Ferrer, Molly J Gasperini, Jeff Goldy, Junitta B. Guzman, Kelly Jin, Shannon Khem, Rana Kutsal, Refugio Martinez, Dakota Newman, Nick Pena, Christine Rimorin, Dana Rocha, Nadiya Shapovalova, Michael Tieu, Natalie Weed, Thomas Zhou, Rebecca A Hodge, Shenqin Yao, Jay Shendure, Kimberly Smith, Ed Lein, Bosiljka Tasic, Boaz P. Levi, Jonathan T. Ting
| Nature Verified
Abstract Cis-acting regulatory enhancer elements are powerful tools for achieving cell type-specific genetic access in adeno-associated virus (AAV) delivery platforms. However, a significant bottleneck in enhancer discovery remains the accurate characterization of their in vivo expression patterns, which currently relies on labor-intensive, gold-standard one-by-one validation.
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