Junne Kamihara

Correction to: Nature Communications https://doi.org/10.1038/s41467-025-57271-1, published online 28 February 2025 In the Acknowledgements section, the name ‘Agnel Sfeir’ was incorrectly given as ‘Agnel Safir’. In addition, the funding from ‘Halvorsen Center for Computational Oncology at Memorial Sloan Kettering Cancer Center’ was omitted. The original article has been corrected.

1 Introduction Pheochromocytomas (PCCs) and paragangliomas (PGLs), collectively PPGL, are rare neuroendocrine tumours arising from chromaffin cells of the adrenal gland and neural crest, respectively. Up to 40% of PPGLs can be hereditary while 30%–40% of sporadic PPGLs harbour a somatic driver mutation [1-3]. It is recommended that all patients undergo genetic testing at the time of diagnosis.

Abstract Somatic mobilization of LINE-1 (L1) has been implicated in cancer etiology. We analyzed a recent TCGA data release comprised of nearly 5000 pan-cancer paired tumor-normal whole-genome sequencing (WGS) samples and ~9000 tumor RNA samples. We developed TotalReCall an improved algorithm and pipeline for detection of L1 retrotransposition (RT), finding high correlation between L1 expression and “RT burden” per sample.