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Articles by Junping Fan
Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection
Keywords SARS-CoV-1 SARS-CoV-2 sarbecoviruses antibody imprinting antigenic divergence neutralizing antibody conserved epitope long-lived memory B cells Get full text access Log in, subscribe or purchase for full access. References 1. Spangler, A. ∙ Shimberg, G.D. ∙ Mantus, G.E. ... Early influenza virus exposure shapes the B cell response to influenza vaccination in individuals 50 years later Immunity. 2025; 58:728-744.e9 2. Guthmiller, J.J. ∙ Yu-Ling Lan, L. ∙ Li, L. ...
Antifungal Prophylaxis and Preemptive Therapy to Prevent COVID-19-Associated Pulmonary Aspergillosis in Patients Requiring Advanced Respiratory Support: A Real-World Cohort Study in China
Keywords COVID-19-associated pulmonary aspergillosis CAPA antifungal prophylaxis preemptive therapy safety Get full text access Log in, subscribe or purchase for full access. References 1. Alanio, A. ∙ Dellière, S. ∙ Fodil, S. ... Prevalence of putative invasive pulmonary aspergillosis in critically ill patients with COVID-19 Lancet Resp. Med. 2020; 8(6):e48-e49 2. Gangneux, J.P. ∙ Dannaoui, E. ∙ Fekkar, A. ...
Biocatalytic production of UDP-glucose from corn stover via DES pre-treatment
Abstract Current UDP-glucose production mainly depends on chemical synthesis, sucrose-based enzymatic routes, or intracellular microbial metabolism, which are limited by high cost, reliance on food-derived substrates, or complex pathway regulation. Direct production of UDP-glucose from non-food lignocellulosic biomass remains largely unexplored.
Genetic basis of phytoalexin-mediated chemical defense in plants
Keywords debneyol chemical defense broad-spectrum resistance biosynthesis 5-epi-aristolochene synthase 5-epi-aristolochene epoxidase epoxide hydrolase 1 MCD1 miR1919 phytoalexin Get full text access Log in, subscribe or purchase for full access. References 1. Dangl, J.L. ∙ Jones, J.D. Plant pathogens and integrated defence responses to infection Nature. 2001; 411:826-833 2. Nimchuk, Z. ∙ Eulgem, T. ∙ Holt, B.F. ... Recognition and response in the plant immune system Annu. Rev. Genet. 2003; 37:579-609 3.
Structural basis of glucosinolate recognition and transport by plant GTR1
Abstract Glucosinolates (GLSs) play crucial roles in plant defense against herbivores. GTR1 facilitates the high-affinity transport of GLSs through a proton-dependent process. However, the molecular mechanism underlying GLS recognition and transport by GTR1 remains largely unknown.
Identification and characterization of bone marrow plasma cells producing IFN-γ-neutralizing autoantibodies in adult-onset immunodeficiency
ArticleOnline now102657Open access Affiliations & Notes 1Comprehensive AIDS Research Center, Pandemic Research Alliance Unit, Center for Infection Biology, School of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijing 100084, China 2School of Biomedical Engineering, Tsinghua University, Beijing 100084, China 3Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China 4Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital,...
Structure and mechanism of the human bile acid transporter OSTα–OSTβ - Nature
Abstract Bile acids (BAs) are crucial amphipathic surfactants that function as multifaceted regulators in various physiological processes, including nutrient absorption and distribution, lipid metabolism and inflammation1,2. The human organic solute transporter αβ (OSTα–OSTβ; hereafter referred to as OSTα/β) is a BA transporter that has a key role in the secretion and distribution of BAs3,4,5,6. Pathogenic mutations in OSTα/β have been associated with cholestasis7,8.
Behind Anti‐MDA5 Antibody: Symbol of A Specific Disease or A Phenomenon?
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Structural basis of TRPV1 inhibition by SAF312 and cholesterol - Nature Communications
Abstract Transient Receptor Potential Vanilloid 1 (TRPV1) plays a central role in pain sensation and is thus an attractive pharmacological drug target. SAF312 is a potent, selective, and non-competitive antagonist of TRPV1 and shows promising potential in treating ocular surface pain. However, the precise mechanism by which SAF312 inhibits TRPV1 remains poorly understood.
Structural insights into double-stranded RNA recognition and transport by SID-1 - Nature Structural & Molecular Biology
Abstract RNA uptake by cells is critical for RNA-mediated gene interference (RNAi) and RNA-based therapeutics. In Caenorhabditis elegans, RNAi is systemic as a result of SID-1-mediated double-stranded RNA (dsRNA) across cells. Despite the functional importance, the underlying mechanisms of dsRNA internalization by SID-1 remain elusive.
Structural Pharmacology of TRPV4 Antagonists
1 Introduction Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4) is a ubiquitously expressed, nonselective, Ca2+-permeable cation channel[1] that belongs to the TRP family.
The evolutionary origin of naturally occurring intermolecular Diels-Alderases from Morus alba - Nature Communications
Abstract Biosynthetic enzymes evolutionarily gain novel functions, thereby expanding the structural diversity of natural products to the benefit of host organisms. Diels-Alderases (DAs), functionally unique enzymes catalysing [4 + 2] cycloaddition reactions, have received considerable research interest. However, their evolutionary mechanisms remain obscure.
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