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Articles by Junping Shi
An international multicenter study of MASLD prevalence among children and adolescents assessed by VCTE
Abstract The worldwide prevalence of pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) remains uncertain. Using vibration-controlled transient elastography (VCTE), we estimate the prevalence of MASLD among children and adolescents in community and hospital populations and conduct additional analyses of hepatic steatosis and fibrosis severity grades.
The role of hepatocyte epigenetics in the pathogenesis of metabolic dysfunction-associated steatotic liver disease
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, and it can progress to cirrhosis and hepatocellular carcinoma (HCC). Genetic susceptibility, the gut microbiota, changes in hepatic metabolic pathways, the regulation of lipid metabolism pathways, cellular interactions in the liver, and epigenetic modifications all significantly contribute to MASLD pathogenesis.
Guidelines for Diagnosis and Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care (2025)
Metabolic dysfunction-associated fatty liver disease (MAFLD), previously referred to as non-alcoholic fatty liver disease, is the most prevalent chronic liver disease worldwide, affecting nearly one-third of adults. The disease spectrum includes simple steatosis, metabolic dysfunction-associated steatohepatitis (MASH), liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC).
Cardiovascular-kidney-metabolic (CKM) syndrome is associated with increased mortality in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) | Communications Medicine
Abstract Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic disorder characterized by pathophysiological interactions among metabolic risk factors. We aimed to determine the prevalence of CKM syndrome and investigate the association between CKM stages and mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
ZnO-S.cerevisiae: An effective growth promoter of Astragalus memeranaceus and nano-antifungal agent against Fusarium oxysporum
Astragalus memeranaceus has been used to treat diseases for thousands of years [1], which is the dried root of legume A.membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or A.membranaceus (Fisch.) Bunge [2]. A.memeranaceus can resist viruses and preserve the myocardium, and exhibits other biological activities, including antiaging, anti-infective, cytoprotective, anti-inflammatory, and antioxidant [3], [4].
Thermally coupled catalytic hydrogen combustion-reverse water gas shift reactor: Model-based feasibility study and parametric analysis
In 2015, 195 member states of the United Nations Framework Convention on Climate Change (UNFCCC) have collectively agreed on the consensus that recognizes the gravity of climate change as an imminent and possibly irreversible threat [1]. Among possible solutions are carbon sequestration and storage (CCS) and carbon capture and utilization (CCU) that is an alternative to CCS.
Efficacy of Cabozantinib and Nivolumab in Treating Hepatocellular Carcinoma with RET Amplification, High Tumor Mutational Burden, and PD‐L1 Expression
Abstract We report on a patient with hepatocellular carcinoma (HCC) who developed bone metastasis after surgery. RET amplification, high tumor mutational burden (TMB; TMB ≥10 mutations per megabase), and programmed death‐ligand 1 (PD‐L1) expression were detected by next‐generation sequencing. Oral administration of cabozantinib was initiated. Nivolumab was added after 1 month.
Effectiveness of Olaparib Treatment in a Patient with Gallbladder Cancer with an ATM‐Inactivating Mutation
Introduction Gallbladder carcinoma (GBC) is a type of biliary tract cancer with a poor prognosis and a high fatality rate. It is commonly diagnosed at an advanced stage and the 5‐year survival is less than 5% 1. Significant risk factors for GBC development include presence of gallstones, chronic inflammation, anomalous pancreatobiliary ductal junctions, advancing age, and female gender 2.
Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway
3-Mercaptopyruvate sulfurtransferase (MPST) is also an important enzyme that contributes to the generation of H 2 S by using 3-mercaptopyruvate as substrate in a pyridoxal-5′-phosphate (PLP)-independent way, which is different from the CBS/CSE system by way of using cysteine as substrate that is dependent on PLP. In this study, we investigated the underlying mechanisms by which fatty acids contribute to the pathogenesis of NAFLD, involving the role of MPST in the development of NAFLD.
Interpretation of liver stiffness measurement based approach for the monitoring of hepatitis B patients with antiviral therapy: a 2-year prospective study - Liang - 2017 - Journal of Viral Hepatitis - Wiley Online Library
Liver biopsy is not routinely performed in treated chronic hepatitis B. Liver stiffness measurement has been validated for non-invasive liver fibrosis assessment in pre-treatment chronic hepatitis B but has not been assessed for fibrosis monitoring during antiviral therapy. Liver stiffness was systemically monitored by Fibroscan® every 6 months in a cohort of patients with hepatitis B receiving antiviral therapy and compared with liver biopsies at baseline and week 104.
Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway
3-Mercaptopyruvate sulfurtransferase (MPST) is also an important enzyme that contributes to the generation of H 2 S by using 3-mercaptopyruvate as substrate in a pyridoxal-5?-phosphate (PLP)-independent way, which is different from the CBS/CSE system by way of using cysteine as substrate that is dependent on PLP. In this study, we investigated the underlying mechanisms by which fatty acids contribute to the pathogenesis of NAFLD, involving the role of MPST in the development of NAFLD.
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