Jüri Habicht on Muck Rack

Jüri Habicht

As seen in: Cell Reports
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Articles

Inflammation induces pro-NETotic neutrophils via TNFR2 signaling

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By Friederike Neuenfeldt, Jan Schumacher, Ricardo Grieshaber-Bouyer, Jüri Habicht
| Cell Reports Verified
Highlights • Priming induces neutrophil diversification into CCR5− and CCR5+ cells • TNFR2 signaling renders CCR5+ neutrophils pro-NETotic by ELANE upregulation • CCR5+ neutrophils appear in the lamina propria of ulcerative colitis patients • Retrograde TNF signaling induces NETosis of CCR5+ neutrophils Summary Cytokines released during chronic inflammatory diseases induce pro-inflammatory properties in polymorphonuclear neutrophils (PMNs).
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