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Kaela M. Varberg on Muck Rack

Kaela M. Varberg

As seen in: Nature, BMJ Open Diabetes Research & Care, BioRxiv
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Articles

NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT

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By Vinay Shukla, Ayelen Moreno Irusta, Kaela M. Varberg, Marija Kuna
| BioRxiv
Abstract Trophoblast stem (TS) cells have the unique capacity to differentiate into specialized cell types, including extravillous trophoblast (EVT) cells. EVT cells invade into and transform the uterus where they act to remodel the vasculature facilitating the redirection of maternal nutrients to the developing fetus. Disruptions in EVT cell development and function are at the core of pregnancy-related disease.
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Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape - Nature Communications

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By Kaela M. Varberg, Joseph M. Varberg, Ross McNally, Khursheed Iqbal, Warren A. Cheung, Takahiro Arima, Michael Soares, Ayelen Moreno-Irusta
| Nature Verified
Abstract The extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited. Here, we map the transcriptome and epigenome landscape as well as chromatin interactions of human trophoblast stem cells and their transition into extravillous trophoblast cells.
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Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity

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By Perinatal Research, Kaela M. Varberg, Jackson Nteeba, Regan L Scott
| BMJ Open Diabetes Research & Care Verified
Pathophysiology/Complications Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity Jackson Nteeba1,2, http://orcid.org/0000-0001-9672-4158Kaela M Varberg1,2, Regan L Scott1,2, Mikaela E Simon1,2, Khursheed Iqbal1,2, Michael J Soares1,2,3,4,5 1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA 2Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City,...
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