Kaiqiong Zhang on Muck Rack

Kaiqiong Zhang

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Articles

Molecular basis of host ATP level modulation by actin-dependent secreted bacterial ATPase and its metaeffector

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By Hongxin Guan, Yu Li, Luhao Zhang, Song Xie, Yuchen Jiang, Chunlin He, Fan Li, Fengjie Zheng, Zhao-Qing Luo, Qi Lai, Jinfu Su, Ningshao Xia, Qingbing Zheng, Jinyu Li, Shaowei Li, Songying Ouyang, Yin-di Jiao, Mengrou Gan, Yiran Sha, Kaiqiong Zhang
| Nature Verified
Abstract Legionella pneumophila employs effectors including kinases, phosphoryl-AMPylases, ATPases, etc. to exploit host ATP for infection. Ceg14, a member of the S-HxxxE family, modulates host-cell energy levels in concert with host actin and the metaeffector AnkJ: actin activates while AnkJ inhibits Ceg14 ATPase activity. However, the molecular basis of this regulation remains unclear.
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