Songying Ouyang

Abstract Legionella pneumophila employs effectors including kinases, phosphoryl-AMPylases, ATPases, etc. to exploit host ATP for infection. Ceg14, a member of the S-HxxxE family, modulates host-cell energy levels in concert with host actin and the metaeffector AnkJ: actin activates while AnkJ inhibits Ceg14 ATPase activity. However, the molecular basis of this regulation remains unclear.

Keywords anti-phage filament Sir2 NAD+ activity Get full text access Log in, subscribe or purchase for full access. References 1. Hille, F. ∙ Richter, H. ∙ Wong, S.P. ... The Biology of CRISPR-Cas: Backward and Forward Cell. 2018; 172:1239-1259 2. Watson, B.N.J. ∙ Steens, J.A. ∙ Staals, R.H.J. ... Coevolution between bacterial CRISPR-Cas systems and their bacteriophages Cell Host Microbe. 2021; 29:715-725 3. Gao, L. ∙ Altae-Tran, H. ∙ Böhning, F. ...

Abstract Adenosine 5′-triphosphate (ATP) is the currency of energy in cells; it plays essential roles in virtually all cellular processes, ranging from basic metabolism to signaling in development and disease. The opportunistic bacterial pathogen Legionella pneumophila utilizes the Dot/Icm type IV secretion system to deliver over 300 effectors into host cells, some of which utilize ATP to perform biochemical reactions catalyzed by their unique enzymatic activities. However, whether L.