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Songying Ouyang

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Articles

Bioengineering strategies for improving the immunogenicity of mRNA vaccines

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By Hong Wang, Ran Zhuo, Junjun Wu, Songying Ouyang
| Nature Verified
Abstract Messenger RNA (mRNA) vaccines have reshaped modern vaccinology by enabling rapid antigen design, scalable manufacturing, and coordinated induction of humoral and cellular immunity. Their clinical success has established mRNA as a versatile platform for infectious diseases, cancer immunotherapy, and emerging therapeutic applications.
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Molecular basis of host ATP level modulation by actin-dependent secreted bacterial ATPase and its metaeffector

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By Hongxin Guan, Yu Li, Luhao Zhang, Song Xie, Yuchen Jiang, Chunlin He, Fan Li, Fengjie Zheng, Zhao-Qing Luo, Qi Lai, Jinfu Su, Ningshao Xia, Qingbing Zheng, Jinyu Li, Shaowei Li, Songying Ouyang, Yin-di Jiao, Mengrou Gan, Yiran Sha, Kaiqiong Zhang
| Nature Verified
Abstract Legionella pneumophila employs effectors including kinases, phosphoryl-AMPylases, ATPases, etc. to exploit host ATP for infection. Ceg14, a member of the S-HxxxE family, modulates host-cell energy levels in concert with host actin and the metaeffector AnkJ: actin activates while AnkJ inhibits Ceg14 ATPase activity. However, the molecular basis of this regulation remains unclear.
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Filament-driven activation of the Kongming antiviral system by deoxyinosine triphosphate

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By Xiangkai Zhen, Yu Li, Zihe Liu, Yang Huang, Xurong Wang, Shuying Xu, Yuchen Jiang, Fan Li, Jinfu Su, Qi Lai, Shaowei Li, Ningshao Xia, Qingbing Zheng, Songying Ouyang
| Cell Press Verified
Keywords anti-phage filament Sir2 NAD+ activity Get full text access Log in, subscribe or purchase for full access. References 1. Hille, F. ∙ Richter, H. ∙ Wong, S.P. ... The Biology of CRISPR-Cas: Backward and Forward Cell. 2018; 172:1239-1259 2. Watson, B.N.J. ∙ Steens, J.A. ∙ Staals, R.H.J. ... Coevolution between bacterial CRISPR-Cas systems and their bacteriophages Cell Host Microbe. 2021; 29:715-725 3. Gao, L. ∙ Altae-Tran, H. ∙ Böhning, F. ...
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