Kairuo Wang on Muck Rack

Kairuo Wang

As seen in: Cell Press, Dove Medical Press
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Articles

Predictive Value of Albumin to Fibrinogen Ratio and CALLY Index for Di

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By Mei Wang, Kairuo Wang, Kairong Su, Sinan Xiao
| Dove Medical Press
Kairong Su,1,* Sinan Xiao,1,* Mei Wang,2 Kairuo Wang,1 Qing Fan,1 Sumei Sha,1 Yongli Cheng,3 Xin Liu,1 Haitao Shi1 1Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Gastroenterology, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, People’s Republic of China; 3Department of Gastroenterology, Xi’an Chang’an District Hospital, Xi’an, Shaanxi, People’s Republic of China...
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Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms

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By Christina Ising, Prabhakar Sairam Andhey, Kairuo Wang
| Cell Press
Highlights • LDLR OX lowers apoE and reduces tau pathology and neurodegeneration in P301S mice • LDLR-overexpressing microglia downregulate Apoe and show suppressed activation • ApoE KO and LDLR OX drive microglial catabolism over anabolism • ApoE KO and LDLR OX increase the OPC pool and preserve myelin integrity Summary APOE is the strongest genetic risk factor for late-onset Alzheimer’s disease. ApoE exacerbates tau-associated neurodegeneration by driving microglial activation.
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