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Kalai Mathee

As seen in: Nature, BioRxiv, Microbiology Research
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Articles

Alternative to invasive bronchoscopy: validating tracheal aspirates for microbiome profiling in intensive care unit pneumonia patients

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By Jun Yeun Cho, Jiyoul Yang, Bumhee Yang, Sun-Hyung Kim, Ki Man Lee, Kang Hyeon Choe, Ok-Jun Lee, Eung-Gook Kim, Kalai Mathee, Giri Narasimhan, Parshatd Govindasamy
| Nature Verified
Abstract Pneumonia causes significant mortality in intensive care unit (ICU) patients, yet traditional culture-based pathogen detection lacks sufficient sensitivity. While bronchoalveolar lavage fluid (BAL) provides optimal diagnostic yield, bronchoscopy is often contraindicated in critically ill patients. This study compares the respiratory microbiome profiles of paired tracheal aspirate (ETA) and BAL samples from pneumonia patients in a tertiary hospital ICU (n=23, November 2019–September 2022).
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Differences in gut microbiota between Dutch and South-Asian Surinamese: potential implications for type 2 diabetes mellitus - Scientific Reports

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By Kalai Mathee
| Nature Verified
Abstract Gut microbiota, or the collection of diverse microorganisms in a specific ecological niche, are known to significantly impact human health. Decreased gut microbiota production of short-chain fatty acids (SCFAs) has been implicated in type 2 diabetes mellitus (T2DM) disease progression. Most microbiome studies focus on ethnic majorities.
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Genomic and metabolic versatility of Pseudomonas aeruginosa contributes to its inter-kingdom transmission and survival

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By Sakthivel Ambreetha, Diansy Zincke, Dananjeyan Balachandar, Kalai Mathee
| Microbiology Research
Article metrics loading... /content/journal/jmm/10.1099/jmm.0.001791 Download as PowerPoint /deliver/fulltext/jmm/73/2/jmm001791.html?itemId=/content/journal/jmm/10.1099/jmm.0.001791&mimeType=html&fmt=ahah References Rice LB. Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. J Infect Dis 2008; 197:1079–1081 [View Article] [PubMed] [Google Scholar] AR Threats Report Antibiotic resistance threats in the United States, 2019. U. S.
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