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Ki Man Lee

As seen in: Nature, ersnet.org
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Articles

Alternative to invasive bronchoscopy: validating tracheal aspirates for microbiome profiling in intensive care unit pneumonia patients

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By Jun Yeun Cho, Jiyoul Yang, Bumhee Yang, Sun-Hyung Kim, Ki Man Lee, Kang Hyeon Choe, Ok-Jun Lee, Eung-Gook Kim, Kalai Mathee, Giri Narasimhan, Parshatd Govindasamy
| Nature Verified
Abstract Pneumonia causes significant mortality in intensive care unit (ICU) patients, yet traditional culture-based pathogen detection lacks sufficient sensitivity. While bronchoalveolar lavage fluid (BAL) provides optimal diagnostic yield, bronchoscopy is often contraindicated in critically ill patients. This study compares the respiratory microbiome profiles of paired tracheal aspirate (ETA) and BAL samples from pneumonia patients in a tertiary hospital ICU (n=23, November 2019–September 2022).
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Mucus plugging, disease severity and sputum myeloperoxidase concentration in bronchiectasis

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By Sun-Hyung Kim, Jin Yoo, Kum Ju Chae, Ki Man Lee
| ersnet.org
Introduction Bronchiectasis is a chronic lung disease in which the bronchi are permanently dilated, causing chronic respiratory symptoms and repeated infections [1]. A key pathological feature of bronchiectasis is impaired mucociliary clearance, which leads to persistent mucus accumulation in the bronchial tree [2]. This accumulation, known as mucus plugging (MP), may play a pivotal role in the pathophysiology of the disease and has significant clinical implications.
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