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Kamwing Jair

As seen in: Cell Press
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Articles

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia

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By Isobel Hawes, Kornel E. Schuebel, Zachary H. Fusfeld, Kamwing Jair
| Cell Press Verified
Figure 8Microglia Reestablish Region-Specific Phenotypes after Ablation and Repopulation(A) Microglial distribution in brain sections from CX3CR1EGFP/+ mice after 2 weeks treatment with CSF1R antagonist PLEX5622 (top panel, PLEX) or 2 weeks of PLEX5622 treatment followed by a 21-day repopulation period (bottom panel, PLEX +21d). Dashed white lines indicate boundaries of VTA, SNc, and SNr.(B) Example dying microglial cell in brain sections from CX3CR1EGFP/+ mice after 1 week of PLEX5622 treatment.
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