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Articles by Kan Lin
Anti-inflammatory, analgesic, and anti-immune-mediated polyarthritis activities of topically applied polarity fractions of Clematis florida var. Plena and their underlying mechanisms
Abstract Background: Clematis florida var. Plena (C. florida) holds significant potential as a topical treatment for immune-mediated polyarthritis (IMPA); however, its active fractions and mechanisms of action remain poorly understood. Given the chemical complexity of herbal remedies, this study adopted a bioactivity- and mechanism-driven approach, focusing on the effects of polarity-based fractions rather than isolated compounds. Methods: C.
Sesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury via m 6 A-dependent regulation of SREBF1 expression
Abstract Objective: This study was designed to elucidate the molecular pathways responsible for anti-atherosclerotic effects of the traditional Chinese medicine formula Yishen Huoxue Huatan, with a focus on its key active component sesamin. Methods: Network pharmacology was applied to predict potential targets and pathways associated with the anti-atherosclerotic activity of Yishen Huoxue Huatan.
Optical coherence tomography-guided confocal Raman microspectroscopy for rapid measurements in tissues
F. Placzek, E. Cordero Bautista, S. Kretschmer, L. M. Wurster, F. Knorr, G. Gonzalez-Cerdas, M. T. Erkkila, P. Stein, C. Ataman, G. G. Hermann, K. Mogensen, T. Hasselager, P. E. Andersen, H. Zappe, J. Popp, W. Drexler, R. A. Leitgeb, and I. W. Schie, “Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy,” Analyst 145(4), 1445–1456 (2020). [Crossref] G. H. Lee, H. Moon, H. Kim, G. H. Lee, W. Kwon, S.
Fiber-optic Raman spectroscopy for in vivo diagnosis of gastric dysplasia
This study aims to assess the clinical utility of a rapid fiber-optic Raman spectroscopy technique developed for enhancing in vivo diagnosis of gastric precancer during endoscopic examination. We have developed a real-time fiber-optic Raman spectroscopy system capable of simultaneously acquiring both fingerprint (FP) (i.e., 800–1800 cm ) and high-wavenumber (HW) (i.e., 2800–3600 cm ) Raman spectra from gastric tissue in vivo at endoscopy.
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