Abstract Systemic anti-tumour immunity results from T cell priming in tumour-draining lymph nodes (TDLNs)1,2,3,4. Although the suppression of T cells in tumours is well characterized5,6,7,8, whether this occurs in TDLNs—and if so, through which mechanisms—remains poorly understood. Here, using imaging mass cytometry of TDLNs from patients with melanoma, we identify a spatial neighbourhood in the TDLN paracortex that is linked to the development of distant metastases.
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