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PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity

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By Anneloes van Krimpen, Julie Huang, Vivian I.V. Gerretsen, Michihisa Umetani, Menno van Nimwegen, Nina E.M. Rozendaal, Thierry van den Bosch, Xinguo Jiang, Angela Liu, Yun-Ru Liu, Yuki Nagasaki, Makoto Murakami, Anne Onrust-van Schoonhoven, Disha Vadgama, Rogier T. A. van Wijck, Eric Bindels, Jan H. von der Thüsen, Antien L. Mooyaart, Febe van Maldegem, Stijn Verwaerde, Rudi W. Hendriks, Bart N. Lambrecht, Dirk J. Grünhagen, Cornelis Verhoef, Joachim G. J. V. Aerts, kan lu, Ralph Stadhouders, Floris Dammeijer, Mike Eterman, Josephine C. Janssen, Kathryn Logronio, Asabi Leliveld, Hedwig Langeveld, Claudia M. Brenis, Li-Fen Lee
| Nature Verified
Abstract Systemic anti-tumour immunity results from T cell priming in tumour-draining lymph nodes (TDLNs)1,2,3,4. Although the suppression of T cells in tumours is well characterized5,6,7,8, whether this occurs in TDLNs—and if so, through which mechanisms—remains poorly understood. Here, using imaging mass cytometry of TDLNs from patients with melanoma, we identify a spatial neighbourhood in the TDLN paracortex that is linked to the development of distant metastases.
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