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Kanbin Wang

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Articles by Kanbin Wang

SCAP downregulation promotes intervertebral disc degeneration through 20-HETE mediated enhancement of macrophage pro-inflammatory responses

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By Chaorong Yu, Yanyan Wang, Haibin Xu, Yuang Zhang, Kanbin Wang, Jinyang Chen, Han Zhou, Wenxuan Zhao, Xiaowen Jiang, Han Chen, Hongru Pan, He Xu, Qixin Chen, Erman Chen, Quan Zhou, Yujie Zhang, Hanxu Huang
| Nature Verified
Abstract Intervertebral disc degeneration (IVDD) is increasingly recognized as an inflammation-driven disorder in which macrophage infiltration plays a pivotal role. Although metabolic pathways regulate macrophage immune responses, the immunometabolic mechanisms connecting macrophage activation and disc degeneration remain unclear. The sterol regulatory element–binding protein cleavage–activating protein (SCAP) was demonstrated as a key regulator of macrophage inflammatory responses.
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Recycling senescent cell lipids for targeted senotherapy

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By Xiaoxiao Ji, Honglu Cai, Peng Tang, Hao Zhou, Jiajie Wang, Yifan Wu, Jinfeng Zhou, zhang Lin, Kaicheng Xu, Changjian Lin, Xiaoyong Wu, Kanbin Wang, Wangmi Liu, Gang Feng, Shigui Yan, Guangyao Jiang, Zihao Qu, Yiying Qi, Xingzi He
| Nature Verified
Abstract Senescent cells (SnCs) are increasingly recognized as key contributors to osteoarthritis, with conventional strategies centered on their elimination. However, senolytic approaches face mounting limitations, driving the need for refined interventions. Here, we exploit SnCs’ lipid metabolic signature to develop a senotherapeutic strategy.
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Osteoblast-derived osteomodulin restrains osteoclastogenesis via ITGB8/RRM2-mediated reduction of mitochondrial respiration and mitochondrial ATP production

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By Xiaowen Jiang, Han Chen, Weiduo Hou, Chengxin Dai, Ruijie Zhang, Erman Chen, Jingjing Zhang, Wanyi Wu, Jianbin Xu, Mo Chen, Liang Liu, Xiaoxiao Ji, Xiaoyong Wu, Kanbin Wang, Xiaohua Yu, Weixu Li, Wei Zhang, Xun Tan, Chaorong Yu
| Nature Verified
Abstract Osteoporosis is driven in part by excessive osteoclast-mediated bone resorption, yet osteoblast-derived extracellular cues that restrain osteoclast bioenergetics remain incompletely defined. Here we identify osteomodulin (OMD), a matrix-associated osteoblast-derived protein that is reduced in the bone tissue and serum of postmenopausal patients with osteoporosis.
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Multifunctional Biomimetic Hematoma Microspheres for Sustained Local Hydrogen Sulfide (H2S) Delivery to Enhance Vascularized Bone Regeneration

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By Chengwei Zhou, Kanbin Wang, Chengxin Dai, Jiayu Chen
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description smll72536-sup-0001-SuppMat.docx4.6 MB Supporting File: smll72536-sup-0001-SuppMat.docx.
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Mitochondria-Targeting Polymeric Micelles for Intervertebral Disc Degeneration Alleviation via Coordinated Cascade Energetic Intervention

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By Han Zhou, Chengzhen Liang, Feng Cheng, Kanbin Wang
| dx.doi.org
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