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Karin G. Hermans on Muck Rack

Karin G. Hermans

As seen in: Cell Reports
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By Gabriela Krivdova, Veronique Voisin, Erwin M. Schoof, Sajid A. Marhon, Alex Murison, Jessica McLeod, Andy Zeng, Stefan Aigner, Brian A. Yee, Alexander A. Shishkin, Martino M. Gabra, Karin G. Hermans, Aaron C. Trotman-Grant
| Cell Reports Verified
Highlights • miR-130a is a regulator of HSC self-renewal and lineage commitment • TBL1XR1 is a principal target of miR-130a • TBL1XR1 loss of function in HSPC phenocopies enforced expression of miR-130a • Elevated miR-130a levels maintain the AML1-ETO repressive program in t(8;21) AML Summary Gene expression profiling and proteome analysis of normal and malignant hematopoietic stem cells (HSCs) point to shared core stemness properties.
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