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Articles by Karin Loré
Accelerating protein design by scaling experimental characterization
Abstract Recent advances in de novo protein design have greatly outpaced standard protein biochemistry workflows, making experimental validation a bottleneck. Here, we describe workflows to address the scale, speed and reproducibility of common in vitro protein testing methods, enabling at least an order of magnitude increase in throughput while reducing wetlab time.
Seasonal influenza mRNA vaccine induces stronger innate and comparable or better adaptive responses than licensed inactivated vaccines
Abstract Seasonal vaccination is the most important strategy for mitigating the large disease burden caused by influenza virus. Licensed inactivated influenza virus vaccines rely on slow, egg-based production, underscoring the need for faster, more effective platforms that elicit robust immune responses.
Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19 - Nature Communications
Study approval The study was approved by the Swedish Ethical Review Authority, and performed according to the Declaration of Helsinki. Written informed consent was obtained from all patients and controls. For sedated patients, the denoted primary contact was contacted and asked about the presumed will of the patient and to give initial oral and subsequently signed written consent. When applicable, retrospective written consent was obtained from patients with non-fatal outcomes.
Innate immune mechanisms of mRNA vaccines
Abbas Y.M. Laudenbach B.T. Martinez-Montero S. Cencic R. Habjan M. Pichlmair A. Damha M.J. Pelletier J. Nagar B. Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc. Natl. Acad. Sci. USA. 2017; 114: E2106-E2115https://doi.org/10.1073/pnas.1612444114 Akinc A. Querbes W. De S. Qin J. Frank-Kamenetsky M. Jayaprakash K.N. Jayaraman M. Rajeev K.G. Cantley W.L. Dorkin J.R. et al.
Immunity to SARS‐CoV‐2 induced by infection or vaccination
Abstract Adaptive immune responses play critical roles in viral clearance and protection against re-infection, and SARS-CoV-2 is no exception. What is exceptional is the rapid characterization of the immune response to the virus performed by researchers during the first 20 months of the pandemic. This has given us a more detailed understanding of SARS-CoV-2 compared to many viruses that have been with us for a long time.
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