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Xaquin Castro Dopico

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Articles

Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex

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By Javier Guenaga, Monika Ádori, Shridhar Bale, Swastik Phulera, Ioannis Zygouras, Fabian-Alexander Schleich, Xaquin Castro Dopico, Miyo Ota, Richard Wilson, Richard and Kimberly Wilson, Jocelyn Cluff, Marco Mandolesi, Wen-Hsin Lee, Agnes Walsh, Mariane B. Melo, Laurent Verkoczy, Darrell J. Irvine, Martin Corcoran, Ian Wilson, Diane G. Carnathan, Guido Silvestri, Andrew Ward, Gabriel Ozorowski, Gunilla B. Karlsson Hedestam, Richard Wyatt, Sashank Agrawal, Tamar Dzvelaia
| Nature Verified
Abstract As a chronically replicating virus, HIV has evolved extreme sequence variability and effective shielding of functionally constrained spike protein determinants by host-derived glycans1. Broadly neutralizing antibodies, although rare, can be isolated from people living with HIV, revealing conserved envelope glycoprotein (Env) sites as key targets for vaccine development2,3,4. One such target is the apex of the Env spike.
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Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies

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By Alexandra A. Fischer, Martin Corcoran, Philip J.M. Brouwer, Mark Chernyshev, Rebecca A. Gillespie, Andrea Nicoletto, Johannes R. Loeffler, James Ferguson, Ioannis Zygouras, Pradeepa Pushparaj, Alesandra J. Rodriguez, Sanjana Narang, Marit van Gils, Xaquin Castro Dopico, Masaru Kanekiyo, Andrew Ward, Julianna Han, Gunilla B. Karlsson Hedestam
| Cell Press Verified
Results Here, we developed and applied ISCAPE for an in-depth analysis of HA-specific B cell responses. We combined personalized genotyping37,38 to define the precise IG germline alleles present in each study participant with the sorting of single antigen-specific B cells for paired HC/LC sequencing and mAb isolation.
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Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer

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By Fabian-Alexander Schleich, Shridhar Bale, Javier Guenaga, Gabriel Ozorowski, Monika Ádori, Xiaohe Lin, Xaquin Castro Dopico, Richard Wilson, Richard and Kimberly Wilson, Mark Chernyshev, Alma Teresia Cotgreave, Marco Mandolesi, Jocelyn Cluff, Esmeralda D. Doyle, Leigh M. Sewall, Wen-Hsin Lee, Shiyu Zhang, Sijy O’Dell, Brandon S. Healy, Deuk Lim, Vanessa R. Lewis, Elana Ben-Akiva, Darrell J. Irvine, Nicole A. Doria-Rose, Martin Corcoran, Diane G. Carnathan, Guido Silvestri, Ian Wilson, Andrew Ward, Richard Wyatt
| Cell Press Verified
Keywords vaccination Env trimers monoclonal antibodies HIV-1 neutralization germline IG genotyping Get full text access Log in, subscribe or purchase for full access. References 1. McCoy, L.E. ∙ Burton, D.R. Identification and specificity of broadly neutralizing antibodies against HIV Immunol. Rev. 2017; 275:11-20 2. Chuang, G.Y. ∙ Geng, H. ∙ Pancera, M. ... Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity J. Virol.
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