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Karl Wagner on Muck Rack

Karl Wagner

As seen in: Nature, Wiley Online Library, MDPI, ACS Publications, Cell Stem Cell, RealClear Defense, The Cipher Brief, PseudoPod
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Articles

In vitro multi-organ invasion model for exploring cardiac resistance to cancer metastasis

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By Amid Shakeri, Dhana Abdo, Sargol Okhovatian, Garrett F. Beeghly, Anna Maria Popovic, Richard Jiang, Chuan Liu, Karl Wagner, Daniel Vosoughi, Jennifer Kieda, Jason E. Fish, Milica Radisic
| Nature Verified
Abstract Despite the systemic spread of cancer, the ventricular myocardium is one of the least common sites of metastasis—a phenomenon that remains poorly understood. To examine this, we develop the Multi-organ Invasion Device (MInD), an organ-on-a-chip platform that enables multi-organ culture under flow. Organ compartments are connected in MInD using PermeoTubes—3D-printed porous conduits that support cancer cell intravasation, migration, and extravasation.
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Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components

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By Neal I. Callaghan, Lauren J. Durland, Wenliang Chen, Uros Kuzmanov, María Miranda, Yu Ding, Zahra Hadavand Mirzaei, Cristine J. Reitz, Renee Gorman, Erika Yan Wang, Karl Wagner, Michelle Kim, Julie Audet, Anthony O. Gramolini, Filio Billia, Milica Radisic, Seema Mital, James Ellis, Peter H. Backx, Craig A. Simmons, Ronald G. Ireland, J. Paul Santerre
| Nature Verified
Abstract Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold tremendous promise for in vitro modeling to assess native myocardial function and disease mechanisms, as well as testing drug safety and efficacy. However, current hiPSC-CMs are functionally immature, resembling in vivo CMs of fetal or neonatal developmental states. The use of targeted culture media and organoid formats have been identified as potential high-yield contributors to improve CM maturation.
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Phytochemical Profile, Acute, and Subacute Toxicity of Spray‐Dried Hydroethanolic Extract From Punica granatum Leaves

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By Alessandra Daniele-Silva, Ingrid Weilack, Andreas Schieber, Karl Wagner
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description cbdv202402429-supp-0001-SuppMat.pdf271.3 KB Supporting Information References 1, , , and , “Therapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials,” Journal of Nutrition and Metabolism 2021 (2021): 5297162.
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