Skip to main content
David W. Kastner on Muck Rack

David W. Kastner

(He/Him)
Boston
As seen in: Nature, Wiley Online Library, ACS Publications, Royal Society of Chemistry, BioRxiv, Cell Press, The Journal of Biological Chemistry
Covers:  protein engineering, bioengineering, molecular dynamics, quantum mechanics
MIT Bioengineering Ph.D. student and artist studying high-valent metalloenzymes. illustratedatom.com
Back to David W. Kastner’s profile

David W. Kastner’s Journalist Portfolio

View as a list
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer

ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer

ASCL1 is a neuroendocrine lineage-specific oncogenic driver of small cell lung cancer (SCLC), highly expresse…

View article →
MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine ...

MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine ...

MYC activates Notch signaling to dedifferentiate neuroendocrine small cell lung cancer (SCLC) in a conserved …

View article →
Impact of Dehydroamino Acids on the Structure and Stability of Incipient 310-Helical Peptides

Impact of Dehydroamino Acids on the Structure and Stability of Incipient 310-Helical Peptides

A comparative study of the impact of small, medium-sized, and bulky α,β-dehydroamino acids (ΔAAs) on the stru…

View article →
Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibe...

Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibe...

The mitochondrial, or intrinsic, apoptosis pathway is regulated mainly by members of the B-cell lymphoma 2 (B…

View article →
Computational Modelling of Peptides Containing Non-Standard Amino Acids

Computational Modelling of Peptides Containing Non-Standard Amino Acids

Peptides represent a class of abundant and potent pharmaceutic compounds. Despite their appeal, the design, s…

View article →
"The Ultimate Triumph of Truth"

"The Ultimate Triumph of Truth"

Valedictorian speech for the graduating class of 2019. The speech emphasizes the importance of interdisciplin…

View article →
Bulky Dehydroamino Acids Enhance Proteolytic Stability and Folding in β-Hairpin Peptides

Bulky Dehydroamino Acids Enhance Proteolytic Stability and Folding in β-Hairpin Peptides

The bulky dehydroamino acids dehydrovaline (ΔVal) and dehydroethylnorvaline (ΔEnv) can be inserted into the t…

View article →
Synthesis and evaluation of potent yaku'amide A analogs

Synthesis and evaluation of potent yaku'amide A analogs

Two full-length analogs of the anticancer peptide yaku'amide A (1a) and four partial structures have been syn…

View article →
Probing the Mechanism of Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxyl...

Probing the Mechanism of Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxyl...

The isonitrile moiety is an electron-rich functionality that decorates various bioactive natural products iso…

View article →
MOFSimplify, machine learning models with extracted stability data of three thousand metal-organi...

MOFSimplify, machine learning models with extracted stability data of three thousand metal-organi...

We report a workflow and the output of a natural language processing (NLP)-based procedure to mine the extant…

View article →
Computational Chemistry To Reveal Nature’s Blueprints for Single-Site Catalysis of C–H Activation

Computational Chemistry To Reveal Nature’s Blueprints for Single-Site Catalysis of C–H Activation

The challenge of activating inert C–H bonds motivates a study of catalysts that draws from what can be accomp…

View article →