Kate M. Rahbari
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Suppressed macrophage responses to quorum-sensing-active Streptococcus pyogenes occurs at the level of the nucleus
Abstract Streptococcus pyogenes, or Group A Streptococus (GAS), a significant human pathogen, employs quorum sensing (QS) systems to coordinate its behavior and genetic regulation in order to enhance survival. Our previous research established that one such QS system, the Rgg2/3 system, can suppress macrophage NFκB activity and production of pro-inflammatory cytokines. Yet, the scope of suppression and the mechanism by which it occurs remains unknown.
A Streptococcus Quorum Sensing System Enables Suppression of Innate Immunity
Editor's Pick Research Article Kate M. Rahbari, Jennifer C. Chang, Michael J. Federle N. Luisa Hiller, Editor DOI: 10.1128/mBio.03400-20 ABSTRACT Some bacterial pathogens utilize cell-cell communication systems, such as quorum sensing (QS), to coordinate genetic programs during host colonization and infection.
Prostaglandin E2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1
Prostaglandin E2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1 Kirsten M. Hooper, Jui-Hung Yen, Weimin Kong, Kate M. Rahbari, Ping-Chang Kuo, Ana M. Gamero, Doina Ganea The Journal of Immunology February 15, 2017, 198 (4) 1521-1530; DOI: 10.4049/jimmunol.1601073
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