Key takeaways Zepbound can affect your period, potentially changing your cycle length and flow. Some people, specifically those who have PCOS, actually see an improvement in their periods after starting a GIP/GLP-1. If you’re taking Zepbound and notice changes in your cycle, let your healthcare provider know. In this article About 1 in 8 people in the United States now take a glucagon-like peptide-1, or GLP-1, medication for weight loss, diabetes, or another condition, according to a KFF poll.