Katlin Recabo on Muck Rack

Katlin Recabo

As seen in: Nature
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Articles

Induced pluripotent stem cell–derived models of malignant nerve sheath tumor progression mimic glial to neuro-mesenchymal transition and uncover therapeutic opportunities

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By Itziar Uriarte-Arrazola, Míriam Magallón-Lorenz, Juana Fernández-Rodríguez, Jiajing Zhang, Emily Lee, Kelli M. Wilson, Ignacio Blanco Verified, Hèctor Salvador, Cleofé Romagosa, Conxi Lázaro, Helena Mazuelas, Bernat Gel, Marc Ferrer, Meritxell Carrió, Eduard Serra, Sara Ortega-Bertran, Edgar Creus-Bachiller, Judit Farrés-Casas, Crystal McKnight, Katlin Recabo
| Nature Verified
Abstract Neurofibromatosis Type 1 (NF1) predisposes to peripheral nerve tumor development. The progression from a benign plexiform neurofibroma (PNF) towards a deadly malignant peripheral nerve sheath tumor (MPNST) is not completely understood but commonly involves the sequential loss of NF1, CDKN2A, and polycomb repressive complex 2 (PRC2). Here we use an iPSC-derived neural crest (NC) model to reproduce this malignant transformation through gene editing.
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