Katriana Nugent on Muck Rack

Katriana Nugent

As seen in: Nature
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Articles

Twist1 overexpression models an aggressive subtype of pancreatic ductal adenocarcinoma in vivo

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By Muhammad Khan, Jinhee Chang, Amol C Shetty, Triet M. Nguyen, Aaron Chan, Priyanshi Patel, Jiayu Chen, Jarey Wang, Matthew Ballew, Francesca Carrieri, Reem Malek, Hailun Wang, Noelle Thielman, Keyu Li, Ryan Park, William L Hwang, Lei Zheng, Kathleen L Gabrielson, Phuoc T. Tran, Audrey Lafargue, Danielle N. Waters, Dipanwita Dutta Chowdhury, Elan Simms, Hwai Wei Tseng, Lucas T. Tran, Katriana Nugent, Ghali Lemtiri-Chlieh
| Nature
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with poor survival outcomes. Genomic analyses have identified distinct molecular subtypes in human PDAC with the quasimesenchymal/squamous/basal-like (QSB) subtype having the worst prognosis. However, no in vivo models exist for QSB subtypes. The epithelial–mesenchymal transition (EMT) transcription factor TWIST1 is upregulated in QSB PDAC.
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