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Katrina Button-Simons

As seen in: Nature, MDPI, BioRxiv
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Articles

Enhancing Gene Co-expression Network Inference for the Malaria Parasite Plasmodium falciparum

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By Qi Li, Katrina Button-Simons, Gabriel Foster, Elias Chahoud
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Using a P. falciparum genetic cross to dissect the relative contributions of pfcrt and plasmepsin II/III to piperaquine response-related traits

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By John Kane, Xue Li, Sudhir Kumar, Katrina Button-Simons
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.06.06.543862 Abstract Piperaquine (PPQ) is widely used in combination with dihydroartemisinin (DHA) as a first-line treatment against malaria parasites. Resistance to this artemisinin combination therapy (ACT) has emerged in Cambodia and threatens to spread to other malaria-endemic regions.
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Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1 - Nature Microbiology

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By Katrina Button-Simons, Xue Li Verified, Sudhir Kumar, Elizabeth Delgado, Richard Pearson, Alexander Taylor, Francois Nosten, Dominic P Kwiatkowski, Ian H. Cheeseman, Simon Avery, David Conway Verified, Ashley M. Vaughan, Katelyn Vendrely Brenneman, Meseret T. Haile, James K. Larbalestier, Michael T. Ferdig
| Nature Verified
Abstract Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is central to the mode of action of several antimalarial drugs. Mutations in the chloroquine (CQ) resistance transporter, pfcrt, located in the digestive vacuole membrane, confer CQ resistance in Plasmodium falciparum, and typically also affect parasite fitness.
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