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Katrina Rae Bueser on Muck Rack

Katrina Rae Bueser

As seen in: Nature
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Articles

Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes

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By Morgan B. Feuz, Claudia C. S. Chini, Gina M. Warner, Gina Lopez, Gustavo Souza, sonu kashyap, Katie Thompson, Sierra Lopez Verified, Thais R. Peclat, Karina S. Kanamori, Fernanda Pereira, Jessica Strange, Rakesh Kaundal, Jason D. Doles, Jennifer L. Rowsey, Joshua N Farr, Sundeep Khosla, Ralph Meyer, Mirella L. Meyer-Ficca, Eduardo N. Chini, Andres Benitez-Rosendo, Katrina Rae Bueser, Delaram Zamani Mazdeh, Alexie E. Zwerdling, Miles K. Wandersee, Sara Peixoto Rabelo, Heidi S. Cordeiro, Naiara C. Lucredi, Luiza Palmieri Serrano
| Nature Verified
Abstract Nicotinamide adenine dinucleotide (NAD) is a metabolic cofactor regulating energy metabolism, epigenetics, DNA repair, and signaling. Although NAD declines with vitamin B3 deficiency, disease, and aging, systemic consequences of chronic depletion remain unclear. Here, we characterize an in vivo model of inducible NAD deficiency using acquired niacin dependency (ANDY) mice, in which NAD synthesis becomes dependent on dietary niacin.
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