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Abdellatif M. Trummer-Herbst V. Koser F. Durand S. Adão R. Vasques-Nóvoa F. Freundt J.K. Voglhuber J. Pricolo M.R. Kasa M. et al. Nicotinamide for the treatment of heart failure with preserved ejection fraction. Sci. Transl. Med. 2021; 13eabd7064 Andersen C. Maier E. Kemmer G. Blass J. Hilpert A.K. Benz R. Reidl J. Porin OmpP2 of Haemophilus influenzae shows specificity for nicotinamide-derived nucleotide substrates. J. Biol. Chem. 2003; 278: 24269-24276 Bagcchi S. Nicotinamide yields impressive results in skin cancer.

Highlights • SAM, Mettl3, and m6A levels are higher in ADPKD • Methionine and SAM promote Mettl3 expression • Mettl3 post-transcriptionally activates cyst-promoting c-Myc and cAMP signaling • Mettl3 deletion or methionine dietary restriction improve ADPKD in mice Summary Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder marked by numerous progressively enlarging kidney cysts.