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Kaustav Das Gupta

As seen in: Nature, Wiley Online Library, Cell Press
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Articles

β-Glucan chitosan particle provides cross-protection against multi-drug-resistant Candida auris

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By Shakti Singh, Ashley Barbarino, Eman G. Youssef, Kaustav Das Gupta, Sunna Nabeela, Teclegiorgis Gebremariam, Sondus Alkhazraji, Priya Uppuluri, Ashraf Ibrahim, Garry Ostroff
| Nature Verified
Abstract Multidrug-resistant fungi, Candida auris, persist in the healthcare environment and colonize human skin and medical devices, causing life-threatening infections with mortality rates approaching ~60% in immunocompromised patients. Because some isolates are resistant to nearly all available antifungal drugs, alternative therapeutic approaches are urgently needed. C. auris cell wall contains β-glucan and highly conserved fungal glycan structures.
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Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease

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By Yizhuo Wang, Kaustav Das Gupta, Divya Ramnath, Rishika Abrol
| Wiley Online Library Verified
Muscle cells Myogenesis is a complex process that involves the differentiation of stem cells to specialised muscle cells [[89]]. HDAC7 plays a crucial role in myogenesis by regulating the migration and differentiation of myoblasts [[90]]. Nuclear Hdac7 limited myoblast differentiation by repressing Mef2c-mediated transcription [[42]]. Hdac7 was present in both the nucleus and cytoplasm of myocytes but was exclusively cytoplasmic after differentiation.
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Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2

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By Kaustav Das Gupta, Melanie R. Shakespear, James E.B. Curson, Ambika M.V. Murthy
| Cell Press Verified
Highlights • The class IIa HDAC, HDAC7, drives TLR4-inducible glycolysis in macrophages • An interaction between HDAC7 and PKM2 drives macrophage immunometabolic responses • Deacetylation of PKM2 at K433 licenses it to drive proinflammatory IL-1β expression • Multiple class IIa HDACs can engage the PKM2 immunometabolic signaling hub Summary Histone deacetylases (HDACs) drive innate immune cell-mediated inflammation.
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