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Kayla Barekat on Muck Rack

Kayla Barekat

As seen in: Nature, BioRxiv, The Journal of Clinical Investigation, Journal of Pharmacology and Experimental Therapeutics
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Articles

Depression of tryptophan may contribute to adverse effects of naproxen - Nature Communications

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By Soumita Ghosh, Nicholas F Lahens, Kayla Barekat, Soon-Yew Tang, Katherine N Theken, Emanuela Ricciotti, Arjun Sengupta, Robin Joshi, Weiming Hu, Frederic Bushman, Aalim M. Weljie, Tilo Grosser, Garret A. FitzGerald
| Nature Verified
Abstract Non-steroidal anti-inflammatory drugs are popular choices for the mitigation of pain and inflammation; however, they are accompanied by adverse effects in the gastrointestinal and cardiovascular systems. Identifying biomarkers and mechanisms for early gastrointestinal or cardiovascular disease detection is desirable.
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Concomitant COX-1 and COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use

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By Kayla Barekat, Soumita Ghosh, Christin Herrmann
| The Journal of Clinical Investigation
Abstract NSAIDs are the most widely used medications for the management of chronic pain; however, they are associated with numerous gastrointestinal (GI) adverse events. Although many mechanisms have been suggested, NSAID-induced enteropathy is thought to be primarily due to inhibition of both COX-1 and -2, which results in suppression of prostaglandin synthesis.
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Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs

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By Soumita Ghosh, Kayla Barekat, Nick Lahens, Soon-Yew Tang
| BioRxiv
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are popular choices for the mitigation of pain and inflammation; however, they are accompanied by side effects in the gastrointestinal and cardiovascular systems. We compared the effects of naproxen, a traditional NSAID, and celecoxib, a cyclooxygenase -2 (Cox-2) inhibitor, in humans. Our findings showed a decrease in tryptophan and kynurenine levels in plasma of volunteers treated with naproxen. We further validated this result in mice.
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