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Articles by Ke Lan
Cross-Neutralizing Antibody Responses to Diverse Coronaviruses in the Human Population
Keywords Coronaviruses SARS-CoV-2 pseudovirus neutralization cross-neutralizing antibodies humoral immunity antigenic cartography genetic distance INTRODUCTION The recurrent emergence of highly pathogenic coronaviruses, including SARS-CoV-1, MERS-CoV, and SARS-CoV-2, highlights their capacity for zoonotic transmission and sustained circulation in human populations.1 Over the past two decades, these viruses have caused multiple outbreaks with substantial global health and socioeconomic...
Host-derived lactic acid disrupts IFN efficacy via antiviral inhibition and proinflammatory amplification
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Abstract Circulating emerging viruses endanger public health. Type I interferons (IFNs) confer robust preclinical antiviral efficacy yet face incompletely defined clinical hurdles: narrow therapeutic windows, suboptimal activity and severe adverse events. Herein, we show that IFNs confer antiviral protection exclusively upon pre-infection administration.
By Mingfu Tian, Siwei Chen, Ju Huang, Xuan Wang, Jianyong Zhu, Moran Li, Hongli Guo, Xu Li, Li Ping Shan, Yuhang Fu, Yijun Tang, Ziyi Zhang, Min Li, Congcong Huang Verified, Na Wang, Lina Sun, Kailang Wu, Qiang Tu, Ke Lan, Zhixin Liu, Zelin Chai, Weixing Du
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Nature
Verified
The role of serum biochemical markers in early prediction of complicated appendicitis: a single-center retrospective analysis
Abstract Studies systematically comparing multiple biochemical markers for differentiating uncomplicated appendicitis (UCA) from complicated appendicitis (CA) specifically in adult populations remain relatively limited. This study aims to identify biochemical markers associated with CA and to establish a predictive model. A retrospective analysis was conducted on the biochemical profiles of patients diagnosed with UCA and CA. Differences between the two groups were analyzed using SPSS.
A modular three in one mucosal vaccine against three antigenic clusters of ACE2 using sarbecoviruses - npj Vaccines
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Abstract The recurrent emergence of ACE2‑using sarbecovirus underscores the need for a broadly protective vaccine. Here, we mapped the antigenic landscape of sarbecovirus receptor-binding domains (RBDs) and identified three distinct clusters. We then engineered a single “three‑in‑one” immunogen, 3Rs-NC, incorporating representative RBDs from each cluster into a single scaffold.
By Lin Liu, Haofeng Lin, Min Li, Xian Li, Shasha Wang, Mengxin Xu, Shuning Liu, Yunqi Hu, Mei-Qin Liu, Zhixiang Huang, Zhen Zhang, Ke Lan, Yu Chen, Huimin Yan, Li Zhou Verified, Qingguo Wu, Yao-Qing Chen, Jingyi Yang
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Nature
Verified
Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID
Keywords long COVID GI sequelae intestinal epithelial repair intestinal stem cell SARS-CoV-2 pathogenesis very-long-chain fatty acid peroxisome PPAR NaPB fenofibrate Get full text access Log in, subscribe or purchase for full access. References 1. Al-Aly, Z. ∙ Topol, E. Solving the puzzle of Long Covid Science. 2024; 383:830-832 2. Davis, H.E. ∙ McCorkell, L. ∙ Vogel, J.M. ... Long COVID: major findings, mechanisms and recommendations Nat. Rev. Microbiol. 2023; 21:133-146 3. Choutka, J. ∙ Jansari, V.
WITHDRAWN: Neutralizing Activity and Viral Escape of Pemivibart by SARS-CoV-2 JN.1 sublineages
Abstract The authors have withdrawn this manuscript because [of a conflict of interest]. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author. Competing Interest Statement The authors have declared no competing interest.
Rewriting Viral Fate: Epigenetic and Transcriptional Dynamics in KSHV Infection
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Neutralizing Activity and Viral Escape of Pemivibart by SARS-CoV-2 JN.1 sublineages
Abstract Pemivibart (Pemgarda/VYD222) was granted Emergency Use Authorization (EUA) by the U.S. Food and Drug Administration (FDA) on March 22, 2024, for COVID-19 pre-exposure prophylaxis in immunocompromised individuals. However, its efficacy and resistance against JN.1 sublineages have yet to be fully characterized.
A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug - Cell Death & Disease
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Abstract SARS-CoV-2 infection is initiated by Spike glycoprotein binding to the human angiotensin-converting enzyme 2 (ACE2) receptor via its receptor binding domain. Blocking this interaction has been proven to be an effective approach to inhibit virus infection. Here we report the discovery of a neutralizing nanobody named VHH60, which was directly produced from an engineering nanobody library based on a commercialized nanobody within a very short period.
By Qianyun Liu, Yuchi Lu, Li Zhou Verified, Huan Yan, Xiuna Yang, Haitao Yang, Hangtian Guo, Ke Lan, Yu Chen, Shin-Chen Hou
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Nature
Verified
The Interplay between KSHV Infection and DNA-Sensing Pathways
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1 - Signal Transduction and Targeted Therapy
Abstract Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic. Here, we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain (RBD) scaffold protein (3R-NC) adjuvanted with a flagellin protein (KFD) (3R-NC + KFDi.n). In mice, the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a year.
Efficacy of dolutegravir + lamivudine q.d. with food in people with TB/HIV using a rifampicin‐based regimen: A retrospective observational case series - Dou - HIV Medicine - Wiley Online Library
CONFLICT OF INTEREST STATEMENT The authors have no conflicts of interest. REFERENCES 1 WHO. Global tuberculosis report 2022. World Health Organization 2022. 2, , , , . Tuberculosis/HIV coinfection and treatment trends - China, 2015–2019. China CDC Wkly. 2020; 2: 924-928. doi:10.46234/ccdcw2020.252 3, , , . HIV-associated tuberculosis. Int J STD AIDS. 2021; 32: 780-790. doi:10.1177/0956462421992257 4, .
Biodegradable Near‐Infrared‐IIb Rare‐Earth Nanoprobe Enables Time‐Programmable Neuroimaging
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202313278-sup-0001-SuppMat.pdf2.2 MB Supporting Information References 1, , Curr. Opin. Chem. Biol. 2023, 76, 102361. 2, , , , Small Struct. 2020, 1, 2000036. 3, , , , , , , , , Lancet Neurol. 2020, 19, 784. 4, , , , , , , , Nat. Biotechnol. 2011, 29, 352. 5, , Trends Neurosci. 2017, 40, 681. 6, , Acta Radiol. 2011, 52, 211. 7, , , , , , , , , , Neuron 2011, 70, 229.
Biodegradable Near‐Infrared‐IIb Rare‐Earth Nanoprobe Enables Time‐Programmable Neuroimaging
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202313278-sup-0001-SuppMat.pdf2.2 MB Supporting Information References 1, , Curr. Opin. Chem. Biol. 2023, 76, 102361. 2, , , , Small Struct. 2020, 1, 2000036. 3, , , , , , , , , Lancet Neurol. 2020, 19, 784. 4, , , , , , , , Nat. Biotechnol. 2011, 29, 352. 5, , Trends Neurosci. 2017, 40, 681. 6, , Acta Radiol. 2011, 52, 211. 7, , , , , , , , , , Neuron 2011, 70, 229.
Hsa_circ_0008133 contributes to lung cancer progression by promoting glycolysis metabolism through the miR‐760/MEX3A axis
CONFLICT OF INTEREST STATEMENT The authors declare that they have no competing interests. REFERENCES 1, , . Correlation of multiple primary lung cancer with bronchial and alveolar epithelial dysplasia. Zhejiang da Xue Xue Bao Yi Xue Ban. 2005; 34(5): 427-431. 2, , , et al. Lung cancer: current therapies and new targeted treatments. Lancet. 2017; 389(10066): 299-311. 3, . Lung cancer in women. Lung Cancer (Auckl). 2012; 3: 79-89. 4, , , et al.
Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge - Signal Transduction and Targeted Therapy
Abstract Coronavirus disease 2019 (COVID-19) was first reported three years ago, when a group of individuals were infected with the original SARS-CoV-2 strain, based on which vaccines were developed.
Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2 - Cell Discovery
Abstract Advanced mRNA vaccines play vital roles against SARS-CoV-2. However, most current mRNA delivery platforms need to be stored at −20 °C or −70 °C due to their poor stability, which severely restricts their availability. Herein, we develop a lyophilization technique to prepare SARS-CoV-2 mRNA-lipid nanoparticle vaccines with long-term thermostability.
Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis
Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis† Ke Lan,a Huabing Yang,a Junping Zheng,a Haiming Hu,a Tianxiang Zhu,a Xiaojuan Zou,a Baifei Hu *a and Hongtao Liu*a Abstract Poria cocos, a widely accepted function food in China, has multiple pharmacological activities.
Close relatives of MERS-CoV in bats use ACE2 as their functional receptors - Nature
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) and several bat coronaviruses use dipeptidyl peptidase-4 (DPP4) as an entry receptor1,2,3,4. However, the receptor for NeoCoV—the closest known MERS-CoV relative found in bats—remains unclear5.
Dream fusion in octahedral spherical hohlraum
I. INTRODUCTION Energy from controlled nuclear fusion has been a quest of scientists worldwide for more than a half a century,1–31. J. Nuckolls, L. Wood, A. Thiessen, and G. Zimmerman, “Laser compression of matter to super-high densities: Thermonuclear (CTR) applications,” Nature 239, 139 (1972). https://doi.org/10.1038/239139a02. J. Lindl, “Development of the indirect-drive approach to inertial confinement fusion and the target physics basis for ignition and gain,” Phys. Plasmas 2, 3933 (1995).
Expression of alpha V integrin is modulated by Epstein-Barr virus nuclear antigen 3C and the metastasis suppressor Nm23-H1 through interaction with the GATA-1 and Sp1 transcription factors
Comments Virology (2006) - pubmed: 16631833 doi: 10.1016/j.virol.2006.03.031 issn: 0042-6822 Tathagata Choudhuri, Subhash C. Verma, Ke Lan, Erle S. Robertson
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