Keijiro Munakata on Muck Rack

Keijiro Munakata

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Articles

Environmental Oxygen Exposure Allows for the Evolution of Interdigital Cell Death in Limb Patterning

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By Ingrid Rosenburg Cordeiro, Kaori Kabashima, Haruki Ochi, Keijiro Munakata
| Cell Press Verified
Highlights • Interdigital cell death (ICD) is correlated with life-history strategy in tetrapods • Atmospheric oxygen modulates local oxygen tension in the interdigital region • High oxygen levels can induce ICD in an amphibian that typically lacks it • Blood vessel density and Bmp signaling are critical for the appearance of ICD Summary Amphibians form fingers without webbing by differential growth between digital and interdigital regions.
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